Quantitative structure− activity relationship of sesquiterpene lactones as inhibitors of the transcription Factor NF-κB

…, V Castro, P Rüngeler, CA Klaas… - Journal of medicinal …, 2004 - ACS Publications
Sesquiterpene lactones (SLs) are the active compounds of a variety of tradionally used
medicinal plants from the Asteraceae family. They are known to possess a considerable …

Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae)

…, A Plaza, R Bauer, E Reininger, CA Klaas… - Journal of …, 2002 - Elsevier
We assessed in vivo the anti-inflammatory activity of two Cat's claw bark extracts, by
comparing a spray-dried hydroalcoholic extract against an aqueous freeze-dried extract, to …

Studies on the anti-inflammatory activity of phytopharmaceuticals prepared from Arnica flowers

CA Klaas, G Wagner, S Laufer, S Sosa… - Planta …, 2002 - thieme-connect.com
Phytopharmaceuticals prepared from flowerheads of Arnica montana of Spanish origin and
of the new type” Arbo”, which can be easily and economically cultivated, were studied for …

[HTML][HTML] Structured Delirium Management in the Hospital: A Randomized Controlled Trial

…, G Hempel, HJ Pavenstädt, C Klaas… - Deutsches Ärzteblatt …, 2022 - ncbi.nlm.nih.gov
Background Delirium is a common and serious complication of inpatient hospital care in
older patients. The current approaches to prevention and treatment followed in German …

Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of …

E Koch, CA Klaas, P Rüngeler, V Castro, G Mora… - Biochemical …, 2001 - Elsevier
Many sesquiterpene lactones (Sls) are known to possess anti-inflammatory activities. To
gain further insight into their structure-activity relationships and the molecular mechanism of …

Barbiturates directly inhibit the calmodulin/calcineurin complex: a novel mechanism of inhibition of nuclear factor of activated T cells

…, T Loop, A Hoetzel, R Schmidt, C Klaas… - Molecular …, 2004 - ASPET
Barbiturates are frequently used for the treatment of intracranial hypertension after brain
injury but their application is associated with a profound increase in the infection rate. The …

Inhibition of the Transcription Factor NF-κB by Sesquiterpene Lactones from Podachaenium eminens1

V Castro, R Murillo, CA Klaas, C Meunier… - Planta …, 2000 - thieme-connect.com
Investigation of Podachaenium eminens afforded nine sesquiterpene lactones (Sls) from
which costunolide, 7-hydroxycostunolide, santamarin as well as 3-chlorodehydroleucodin are …

[HTML][HTML] Conception of a new 4-quadrant hydrogen compressed air energy storage power plant with an integrated electrolyzer

HP Beck, AK Klaas, C Klaas - Energy Reviews, 2024 - Elsevier
A hydrogen compressed air energy storage power plant with an integrated electrolyzer is ideal
for large-scale, long-term energy storage because of the emission-free operation and the …

NF-κB DNA binding activity of sesquiterpene lactones from Anthemis arvensis and Anthemis cotula

I Vučković, L Vujisić, CA Klaas, I Merfort… - Natural Product …, 2011 - Taylor & Francis
Previous investigations of Anthemis arvensis L. and Anthemis cotula L., species growing
wild in Serbia, revealed linear sesquiterpene lactones (SLs) with unusual types of skeleton, …

Therapeutic drug monitoring of antibiotics in critically ill patients

D Horn, C Klaas, M Fobker, R Köck… - Handbook of Analytical …, 2020 - Elsevier
The basic principle of therapeutic drug monitoring (TDM) is the quantification of drug
concentrations in body fluids, mostly from venous blood samples, for optimizing drug dosage, …