Since its first description 20 years ago, the tetrazolium-based colorimetric (MTT) assay using
MT-4 cells for the detection of anti-HIV compounds has been widely used. This method, …

A number of novel 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives, containing
the adamantyl moiety, were synthesized and examined in various viral test systems. No …

A series of 2-(2,6-dihalophenyl)-3-(substituted pyrimidinyl)-1,3-thiazolidin-4-ones were
designed on the prediction of quantitative structure–activity relationship (QSAR) studies, …

This work follows on from our initial discovery of a series of piperidine-substituted thiophene[3,2-d]pyrimidine
HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTI) ( J. Med. …

New N-acetyl (5–8) and N-thiocarbamoyl (9–12) derivatives of 4,5-dihydropyrazole were
synthesized starting from α,β-unsaturated ketones under the effect of hydrazine hydrate and …

We describe the antiviral activity of plant lectins with specificity for different glycan structures
against the severe acute respiratory syndrome coronavirus (SARS-CoV) and the feline …

Design, synthesis and anti-HIV activity of a series of 2,3-diaryl-1,3-thiazolidin-4-ones are
reported. Some derivatives proved to be highly effective in inhibiting HIV-1 replication at …

The early effectiveness of combinatorial antiretroviral therapy (cART) in the treatment of HIV
infection has been compromised to some extent by rapid development of multidrug-resistant …

During the last forty years we have witnessed impressive advances in the field of antiviral
drug discovery culminating with the introduction of therapies able to stop human …

Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …