Real-life assessment of the multidimensional nature of dyspnoea in COPD outpatients
…, P Devillier, A Didier, T Perez, C Pignier… - European …, 2016 - Eur Respiratory Soc
Dyspnoea is a prominent symptom of chronic obstructive pulmonary disease (COPD). Recent
multidimensional dyspnoea questionnaires like the Multidimensional Dyspnea Profile (…
multidimensional dyspnoea questionnaires like the Multidimensional Dyspnea Profile (…
Sarcoplasmic Reticulum Ca2+ Refilling Controls Recovery From Ca2+-Induced Ca2+ Release Refractoriness in Heart Muscle
P Szentesi, C Pignier, M Egger, EG Kranias… - Circulation …, 2004 - Am Heart Assoc
In cardiac muscle Ca 2+ -induced Ca 2+ release (CICR) from the sarcoplasmic reticulum (SR)
is initiated by Ca 2+ influx via L-type Ca 2+ channels. At present, the mechanisms …
is initiated by Ca 2+ influx via L-type Ca 2+ channels. At present, the mechanisms …
Sodium late current blockers in ischemia reperfusion: is the bullet magic?
B Le Grand, C Pignier, R Létienne… - Journal of medicinal …, 2008 - ACS Publications
We describe the discovery of the first selective, potent, and voltage-dependent inhibitor of
the late current mediated by the cardiac sodium channel Na V 1.5. The compound 3,4-dihydro-…
the late current mediated by the cardiac sodium channel Na V 1.5. The compound 3,4-dihydro-…
[HTML][HTML] The multidimensional nature of dyspnoea in amyotrophic lateral sclerosis patients with chronic respiratory failure: air hunger, anxiety and fear
…, E de Bock, B Aguilaniu, P Devillier, C Pignier… - Respiratory …, 2018 - Elsevier
Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder leading to
chronic respiratory failure. Few studies have investigated ALS-related dyspnoea, and none …
chronic respiratory failure. Few studies have investigated ALS-related dyspnoea, and none …
Discovery of novel protease activated receptors 1 antagonists with potent antithrombotic activity in vivo
…, S Marrot, R Letienne, C Pignier… - Journal of medicinal …, 2009 - ACS Publications
Protease activated receptors (PARs) or thrombin receptors constitute a class of G-protein-coupled
receptors (GPCRs) implicated in the activation of many physiological mechanisms. …
receptors (GPCRs) implicated in the activation of many physiological mechanisms. …
Characterization of nifedipine-resistant calcium current in neonatal rat ventricular cardiomyocytes
C Pignier, D Potreau - American Journal of Physiology …, 2000 - journals.physiology.org
Calcium current was recorded from ventricular cardiomyocytes of rats at various stages of
postnatal development using the whole cell patch-clamp technique. In cultured 3-day-old …
postnatal development using the whole cell patch-clamp technique. In cultured 3-day-old …
Direct protective effects of poly-unsaturated fatty acids, DHA and EPA, against activation of cardiac late sodium current: a mechanism for ischemia selectivity
C Pignier, C Revenaz, I Rauly-Lestienne… - Basic research in …, 2007 - Springer
Polyunsaturated fatty acids (PUFAs) such as docosahexaenoic and eicosapentaenoic acids
(DHA, EPA) exert ischemic anti-arrhythmic effects. However, their mechanism of action …
(DHA, EPA) exert ischemic anti-arrhythmic effects. However, their mechanism of action …
KC 12291: an atypical sodium channel blocker with myocardial antiischemic properties
…, R Létienne, B Le Grand, C Pignier… - Cardiovascular drug …, 2004 - Wiley Online Library
KC 12291 was designed as a voltage‐gated sodium channel (VGSC) blocker with cardioprotective
properties. KC 12291 has moderate inhibitory effects on peak (or rapid) Na + current, …
properties. KC 12291 has moderate inhibitory effects on peak (or rapid) Na + current, …
Protease-activated receptor-1 mediates thrombin-induced persistent sodium current in human cardiomyocytes
…, S Sablayrolles, B Le Grand, C Pignier… - Molecular …, 2008 - ASPET
After the thrombus formation in cardiac cavities or coronaries, the serine protease thrombin
is produced and can therefore reach the myocardial tissue by the active process of …
is produced and can therefore reach the myocardial tissue by the active process of …
Na+ Currents in Cardioprotection: Better to Be Late
B Le Grand, C Pignier, R Létienne… - Journal of medicinal …, 2009 - ACS Publications
We report the discovery of a selective, potent inhibitor of the late current mediated by the
cardiac isoform of the sodium channel (Na V 1.5). The compound, 3,4-dihydro-N-[(2S)-3-[(2-…
cardiac isoform of the sodium channel (Na V 1.5). The compound, 3,4-dihydro-N-[(2S)-3-[(2-…