The tumor microenvironment is a complex system that involves the interaction between
malignant and neighbor stromal cells embedded in a mesh of extracellular matrix (ECM) …

Advances in nanomaterials science contributed in recent years to develop new devices and
systems in the micro and nanoscale for improving the diagnosis and treatment of cancer. …

Introduction Genomic and transcriptomic alterations affecting key cellular processes such us
cell proliferation, differentiation and genomic stability are considered crucial for the …

Reactive oxygen species (ROS) are implicated in tumor transformation. The antioxidant
system (AOS) protects cells from ROS damage. However, it is also hijacked by cancers cells to …

G protein-coupled receptor signaling does not result from sequential activation of a linear
pathway of proteins/enzymes, but rather from complex interactions of multiple, branched …

It is well established that histamine modulates cell proliferation through the activation of the
histamine H1 receptor (H1R), a G protein-coupled receptor (GPCR) that is known to couple …

Histamine and H2 agonists transiently induce an important cAMP response in promonocytic
U-937 cells but fail to induce monocytic differentiation because of a rapid receptor …

Advanced melanoma is the most aggressive form of skin cancer. It is highly metastatic and
dysfunctional in melanogenesis; two processes that are induced by H 2 O 2. This work …

The Cyclin-dependent kinase inhibitor 1B (p27Kip1) is a key protein in the decision between
proliferation and cell cycle exit. Quiescent cells show nuclear p27Kip1, but this protein is …

The incidence of melanoma has been increasing at an alarming rate worldwide. Although
melanoma accounts for only 10% of skin cancer, it is responsible for at least 80% of skin …