There is much evidence to support a role for natural killer (NK) cells in controlling the
progression of multiple myeloma (MM), a malignancy characterized by an abnormal plasma cell …

The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly
diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal …

Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important effectors
of anticancer immune response. These cells can survey and control tumor initiation due …

NKG2D and DNAM-1 are two activating receptors, present on the surface of NK cells and
other cells of the immune system. Their ligands – MICA, MICB, ULBP1-6 for NKG2D, PVR/…

Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic
development, growth, and metastatic dissemination in a process called cancer …

Exosomes are a class of nanovesicles formed and released through the late endosomal
compartment and represent an important mode of intercellular communication. The ability of …

Modulation of the host immune system represents a promising therapeutic approach
against cancer, including multiple myeloma. Recent findings indicate that the NK group 2D (NKG2D)…

Increasing evidence indicates that cancer cell stress induced by chemotherapeutic agents
promote antitumor immune responses and contribute to their full clinical efficacy. In this article, …

BACKGROUND/AIMS: Unresponsiveness to IFN-α is common in chronic hepatitis C. Since
conditions associated with an increased oxidative stress (advanced age, steatosis, fibrosis, …

Genotoxic stress can promote antitumor NK cell responses by upregulating the surface
expression of activating ligands on cancer cells. Moreover, a number of studies suggested a role …