p53 status may be a determinant of chemosensitivity of tumor cells; however, its involvement
in cellular resistance to cisplatin remains uncertain. To investigate the relationships …

Multinuclear platinum compounds have been designed to circumvent the cellular resistance
to conventional platinum-based drugs. In an attempt to examine the cellular basis of the …

The stable nitroxide 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) is widely used
as a probe in biophysical studies and as an antioxidant in several experimental models. …

Multinuclear platinum compounds have been designed to circumvent the cellular resistance
to conventional mononuclear platinum-based drugs. In this study we performed a …

Background: Although doxorubicin remains one of the most effective agents for the
treatment of solid tumors, there is an intensive effort to synthesize doxorubicin analogues (…

The Po river plain (northern Italy) is delimited to two mountain ridges, the Alps and the
Apennines. It hosts peculiar lowland man-modified springs, locally known as “fontanili”, which …

On the basis of a structure-activity study of a new series of anthracycline disaccharides, we
recently identified a doxorubicin analogue (MEN 10755) with a promising antitumor activity. …

The effect of topotecan, a topoisomerase I inhibitor, on ionizing radiation‐induced cytotoxicity
was studied in 2 human tumor cell lines characterized by a different expression of the …

The amino sugar is recognized to be a critical determinant of the activity of anthracycline
monosaccharides related to doxorubicin and daunorubicin. In an attempt to improve the …

Preclinical and clinical studies have documented the pharmacological interest in
camptothecin derivatives in the treatment of resistant tumors. In particular, topotecan, a water-soluble …