User profiles for Claudio Pisano
claudio pisanoBiogem Verified email at biogem.it Cited by 8909 |
[HTML][HTML] Modulation of the heparanase-inhibiting activity of heparin through selective desulfation, graded N-acetylation, and glycol splitting
Heparanase is an endo-β-glucuronidase that cleaves heparan sulfate (HS) chains of heparan
sulfate proteoglycans on cell surfaces and in the extracellular matrix (ECM). Heparanase, …
sulfate proteoglycans on cell surfaces and in the extracellular matrix (ECM). Heparanase, …
Significance of heparanase in cancer and inflammation
Heparan sulfate proteoglycans (HSPGs) are primary components at the interface between
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …
virtually every eukaryotic cell and its extracellular matrix. HSPGs not only provide a storage …
SST0001, a chemically modified heparin, inhibits myeloma growth and angiogenesis via disruption of the heparanase/syndecan-1 axis
Purpose: Heparanase promotes myeloma growth, dissemination, and angiogenesis through
modulation of the tumor microenvironment, thus highlighting the potential of therapeutically …
modulation of the tumor microenvironment, thus highlighting the potential of therapeutically …
Heparanase is essential for the development of diabetic nephropathy in mice
…, T Van Kuppevelt, A Meirovitz, C Pisano… - Diabetes, 2012 - Am Diabetes Assoc
Diabetic nephropathy (DN) is the major life-threatening complication of diabetes. Abnormal
permselectivity of glomerular basement membrane (GBM) plays an important role in DN …
permselectivity of glomerular basement membrane (GBM) plays an important role in DN …
Paclitaxel and Cisplatin-induced neurotoxicity: a protective role of acetyl-L-carnitine
C Pisano, G Pratesi, D Laccabue, F Zunino… - Clinical Cancer …, 2003 - AACR
Purpose: Antineoplastic drugs belonging to platinum or taxane families are severely
neurotoxic, inducing the onset of disabling peripheral neuropathies with different clinical signs. …
neurotoxic, inducing the onset of disabling peripheral neuropathies with different clinical signs. …
Chromatin and microtubule organization during premeiotic, meiotic and early postmeiotic stages of Drosophila melanogaster spermatogenesis
Larval and pupal testes of Drosophila melanogaster were fixed with a methanol/acetone
fixation procedure that results in good preservation of cell morphology; fixed cells viewed by …
fixation procedure that results in good preservation of cell morphology; fixed cells viewed by …
Development and therapeutic impact of HDAC6-selective inhibitors
S Dallavalle, C Pisano, F Zunino - Biochemical pharmacology, 2012 - Elsevier
Histone deacetylases (HDAC) play a key role in regulating gene expression by deacetylating
histones. Some HDAC isoforms can also modulate the function of nonhistone proteins …
histones. Some HDAC isoforms can also modulate the function of nonhistone proteins …
Novel camptothecin analogue (gimatecan)‐containing liposomes prepared by the ethanol injection method
P Stano, S Bufali, C Pisano, F Bucci… - Journal of liposome …, 2004 - Taylor & Francis
Small‐sized liposomes have several advantages as drug delivery systems, and the ethanol
injection method is a suitable technique to obtain the spontaneous formation of liposomes …
injection method is a suitable technique to obtain the spontaneous formation of liposomes …
[HTML][HTML] Heparanase-mediated loss of nuclear syndecan-1 enhances histone acetyltransferase (HAT) activity to promote expression of genes that drive an aggressive …
Heparanase acts as a master regulator of the aggressive tumor phenotype in part by enhancing
expression of proteins known to drive tumor progression (eg VEGF, MMP-9, hepatocyte …
expression of proteins known to drive tumor progression (eg VEGF, MMP-9, hepatocyte …
The potential of heparanase as a therapeutic target in cancer
C Pisano, I Vlodavsky, N Ilan, F Zunino - Biochemical pharmacology, 2014 - Elsevier
Heparanase has generated substantial interest as therapeutic target for antitumor therapy,
because its activity is implicated in malignant behavior of cancer cells and in tumor …
because its activity is implicated in malignant behavior of cancer cells and in tumor …