Nitric oxide reverts the resistance to doxorubicin in human colon cancer cells by inhibiting the drug efflux

C Riganti, E Miraglia, D Viarisio, C Costamagna… - Cancer research, 2005 - AACR
Multidrug resistance (MDR) is a phenomenon by which cancer cells evade the cytotoxic
effects of chemotherapeutic agents. It may occur through different mechanisms, but it often …

[HTML][HTML] Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress

…, E Gazzano, M Polimeni, C Costamagna… - Journal of Biological …, 2004 - ASBMB
Diphenyleneiodonium (DPI) and the structurally related compound diphenyliodonium (DIP)
are widely used as inhibitors of flavoenzymes, particularly NADPH oxidase. Here we report …

[HTML][HTML] Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation

…, D Atragene, L Bergandi, C Riganti, C Costamagna… - FEBS letters, 2003 - Elsevier
Artemisinin is a natural product used as an alternative drug in the treatment of severe and
multidrug-resistant malaria. In the present work we show that artemisinin shares with other …

Fluoride effects: the two faces of janus

…, E Aldieri, S Doublier, C Costamagna… - Current medicinal …, 2010 - ingentaconnect.com
The behavior of fluoride ions in the human organism is a classic example of double-edged
sword. On the one hand the daily supplementation with fluoride is undoubtedly an important …

Insulin stimulates nitric oxide synthesis in human platelets and, through nitric oxide, increases platelet concentrations of both guanosine-3′, 5′-cyclic …

…, G Anfossi, P Massucco, L Mattiello, C Costamagna… - Diabetes, 1997 - Am Diabetes Assoc
The insulin-induced platelet anti-aggregating effect is attributed to a nitric oxide (NO)-mediated
increase of cyclic guanosine monophosphate (cGMP). The aim of this work, carried out in …

Liposome-encapsulated doxorubicin reverses drug resistance by inhibiting P-glycoprotein in human cancer cells

…, G Montorfano, E Enrico, C Costamagna… - Molecular …, 2011 - ACS Publications
The most frequent drawback of doxorubicin is the onset of drug resistance, due to the active
efflux through P-glycoprotein (Pgp). Recently formulations of liposome-encapsulated …

Na+/H+ exchanger activity is increased in doxorubicin‐resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin

…, D Viarisio, C Riganti, C Costamagna… - … journal of cancer, 2005 - Wiley Online Library
Multidrug resistant (MDR) tumor cells exhibit an altered pH gradient across different cell
compartments, which favors a reduced intracellular accumulation of antineoplastic drugs and a …

Mitochondria-targeted doxorubicin: a new therapeutic strategy against doxorubicin-resistant osteosarcoma

…, M Fanelli, IC Salaroglio, C Costamagna… - Molecular cancer …, 2016 - AACR
Doxorubicin is one of the leading drugs for osteosarcoma standard chemotherapy. A total of
40% to 45% of high-grade osteosarcoma patients are unresponsive, or only partially …

Chloroquine stimulates nitric oxide synthesis in murine, porcine, and human endothelial cells.

…, E Aldieri, R Todde, C Costamagna… - The Journal of …, 1998 - Am Soc Clin Investig
Nitric oxide (NO) is a free radical involved in the regulation of many cell functions and in the
expression of several diseases. We have found that the antimalarial and antiinflammatory …

Signaling pathway of nitric oxide-induced acrosome reaction in human spermatozoa

A Revelli, C Costamagna, F Moffa, E Aldieri… - Biology of …, 2001 - academic.oup.com
Nitric oxide (NO) has been recently shown to modulate in vitro motility, viability, the acrosome
reaction (AR), and metabolism of spermatozoa in various mammalian species, but the …