Specific contributions of histone tails and their acetylation to the mechanical stability of nucleosomes
B Brower-Toland, DA Wacker, RM Fulbright… - Journal of molecular …, 2005 - Elsevier
The distinct contributions of histone tails and their acetylation to nucleosomal stability were
examined by mechanical disruption of individual nucleosomes in a single chromatin fiber …
examined by mechanical disruption of individual nucleosomes in a single chromatin fiber …
The DNA binding and catalytic domains of poly (ADP-ribose) polymerase 1 cooperate in the regulation of chromatin structure and transcription
DA Wacker, DD Ruhl, EH Balagamwala… - … and cellular biology, 2007 - Am Soc Microbiol
We explored the mechanisms of chromatin compaction and transcriptional regulation by
poly (ADP-ribose) polymerase 1 (PARP-1), a nucleosome-binding protein with an NAD+-…
poly (ADP-ribose) polymerase 1 (PARP-1), a nucleosome-binding protein with an NAD+-…
[HTML][HTML] A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19
…, NW Cummins, NE Ingraham, DA Wacker… - …, 2021 - thelancet.com
Background The SARS-CoV-2 virus enters cells via Angiotensin-converting enzyme 2 (ACE2),
disrupting the renin-angiotensin-aldosterone axis, potentially contributing to lung injury. …
disrupting the renin-angiotensin-aldosterone axis, potentially contributing to lung injury. …
Efficacy of losartan in hospitalized patients with COVID-19–induced lung injury: a randomized clinical trial
…, LH Merck, BE Driver, DA Wacker… - JAMA network …, 2022 - jamanetwork.com
Importance SARS-CoV-2 viral entry may disrupt angiotensin II (AII) homeostasis, contributing
to COVID-19 induced lung injury. AII type 1 receptor blockade mitigates lung injury in …
to COVID-19 induced lung injury. AII type 1 receptor blockade mitigates lung injury in …
[HTML][HTML] Evaluating vitamin C in septic shock: a randomized controlled trial of vitamin C monotherapy
DA Wacker, SL Burton, JP Berger, AJ Hegg… - Critical care …, 2022 - journals.lww.com
… Wacker’s institution received funding from the University of Minnesota Critical Care
Program for an unrelated project, the University of Minnesota Foundation, and the Fairview …
Program for an unrelated project, the University of Minnesota Foundation, and the Fairview …
Site-specific incorporation of nonnatural residues during in vitro protein biosynthesis with semi-synthetic aminoacyl-tRNAs
JD Bain, ES Diala, CG Glabe, DA Wacker, MH Lyttle… - Biochemistry, 1991 - ACS Publications
Departments of Biological Chemistry, Chemistry, and Molecular Biology and Biochemistry,
University of California at Irvine, Irvine, California 92717, Department of Pediatrics, University …
University of California at Irvine, Irvine, California 92717, Department of Pediatrics, University …
Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases.
DA Wacker, KJ Miller - Current opinion in drug discovery & …, 2008 - europepmc.org
The serotonin 5-HT2C receptor is a G-protein-coupled receptor and is one of the 14 subtypes
that constitutes the serotonin receptor family. Agonists of 5-HT2C have been implicated as …
that constitutes the serotonin receptor family. Agonists of 5-HT2C have been implicated as …
Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an Antidiabetic Clinical …
DA Wacker, Y Wang, M Broekema, K Rossi… - 2014 - ACS Publications
G-protein-coupled receptor 119 (GPR119) is expressed predominantly in pancreatic β-cells
and in enteroendocrine cells in the gastrointestinal tract. GPR119 agonists have been …
and in enteroendocrine cells in the gastrointestinal tract. GPR119 agonists have been …
Regulation of chromatin structure and chromatin-dependent transcription by poly (ADP-ribose) polymerase-1: possible targets for drug-based therapies
Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly expressed
member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units …
member of a family of PARPs that catalyze the polymerization of ADP-ribose (ADPR) units …
Discovery of BMS-986339, a pharmacologically differentiated farnesoid X receptor agonist for the treatment of nonalcoholic steatohepatitis
…, MG Soars, BA Ellsworth, DA Wacker - Journal of Medicinal …, 2022 - ACS Publications
While several farnesoid X receptor (FXR) agonists under clinical investigation for the treatment
of nonalcoholic steatohepatitis (NASH) have shown beneficial effects, adverse effects …
of nonalcoholic steatohepatitis (NASH) have shown beneficial effects, adverse effects …