Background— Inflammation is a feature of pulmonary arterial hypertension (PAH), and
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …

The autotaxin–lysophophatidic acid (ATX–LPA) signaling pathway is implicated in a variety
of human disease states including angiogenesis, autoimmune diseases, cancer, fibrotic …

When a typical glutamate-containing neurone fires, an action potential is propagated down
the branching axon through more than a thousand varicosities. At each of these release sites …

The preclinical model of bleomycin-induced lung fibrosis, used to investigate mechanisms
related to idiopathic pulmonary fibrosis (IPF), has incorrectly predicted efficacy for several …

The incidence of chronic kidney diseases (CKD) is constantly rising, reaching epidemic
proportions in the western world and leading to an enormous threat, even to modern health‐care …

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease of high unmet medical need.
Although bromodomain (Brd) and extra terminal domain isoforms have recently been …

Mutations in bone morphogenetic protein receptor II (BMPR-II) underlie most heritable
cases of pulmonary arterial hypertension (PAH). However, less than half the individuals who …

The records of 146 consecutive patients with mastectomy operations over a three year
period were reviewed. Of these, ninety-three (63.6 per cent) had one or more complications …

Mutations in the bone morphogenetic protein (BMP) type II receptor (BMPR-II) underlie most
cases of heritable pulmonary arterial hypertension (HPAH) and a significant proportion of …

Mutations in the gene for the transforming growth factor (TGF)-β superfamily receptor, bone
morphogenetic protein receptor II, underlie heritable forms of pulmonary arterial …