Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene
C Guillemette, JK Ritter, DJ Auyeung… - Pharmacogenetics …, 2000 - journals.lww.com
One of the most important mechanisms involved in host defense against xenobiotic
chemicals and endogenous toxins is the glucuronidation catalysed by UDP-glucuronosyltransferase …
chemicals and endogenous toxins is the glucuronidation catalysed by UDP-glucuronosyltransferase …
[PDF][PDF] Expression and inducibility of the human bilirubin UDP‐glucuronosyltransferase UGT1A1 in liver and cultured primary hepatocytes: Evidence for both genetic …
…, MT Thompson, AD Grove, DJ Auyeung… - …, 1999 - Wiley Online Library
In Crigler‐Najjar type II patients and, recently, in Crigler‐Najjar type I patients treated with
human hepatocyte cell therapy, phenobarbital has been used for reducing the serum bilirubin …
human hepatocyte cell therapy, phenobarbital has been used for reducing the serum bilirubin …
Mechanism of rat UDP-glucuronosyltransferase 1A6 induction by oltipraz: evidence for a contribution of the Aryl hydrocarbon receptor pathway
DJ Auyeung, FK Kessler, JK Ritter - Molecular pharmacology, 2003 - ASPET
The utility of oltipraz as a cancer chemopreventive agent is thought to depend on the
induction of enzymes involved in phase 2 xenobiotic detoxification. Although studies of some …
induction of enzymes involved in phase 2 xenobiotic detoxification. Although studies of some …
Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases
FK Kessler, MR Kessler, DJ Auyeung… - Drug metabolism and …, 2002 - ASPET
Gunn rats glucuronidate acetaminophen (APAP) at reduced rates and show increased
susceptibility to APAP-induced hepatotoxicity. This defect is presumed to involve UDP-…
susceptibility to APAP-induced hepatotoxicity. This defect is presumed to involve UDP-…
Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8
LJ Webb, KK Miles, DJ Auyeung, FK Kessler… - Drug metabolism and …, 2005 - ASPET
The UGT1 complex codes for a subfamily of homologous “1A7-like” UDP-glucuronosyltransferases
(UGTs), including UGT1A7 and UGT1A8. Little information is available regarding …
(UGTs), including UGT1A7 and UGT1A8. Little information is available regarding …
Involvement of hepatocyte nuclear factor 1 in the regulation of the UDP-glucuronosyltransferase 1A7 (UGT1A7) gene in rat hepatocytes
RP Metz, DJ Auyeung, FK Kessler, JK Ritter - Molecular Pharmacology, 2000 - ASPET
UDP-glucuronosyltransferase 1A7 (UGT1A7) is a major UGT contributing to the glucuronidation
of xenobiotic phenols in rats. Its expression in rat liver is tightly regulated, with low …
of xenobiotic phenols in rats. Its expression in rat liver is tightly regulated, with low …
Developmental and peri-postnatal study in cynomolgus monkeys with belimumab, a monoclonal antibody directed against B-lymphocyte stimulator
DJ Auyeung-Kim, MN Devalaraja, TS Migone… - Reproductive …, 2009 - Elsevier
Belimumab is a fully human monoclonal antibody antagonist for soluble B-lymphocyte stimulator,
and is a potential therapeutic for various autoimmune disorders. To support clinical use…
and is a potential therapeutic for various autoimmune disorders. To support clinical use…
An alternative promoter contributes to tissue-and inducer-specific expression of the rat UDP-glucuronosyltransferase 1A6 gene
DJ Auyeung, FK Kessler, JK Ritter - Toxicology and applied pharmacology, 2001 - Elsevier
UDP-glucuronosyltransferase 1A6 (UGT1A6), a key enzyme catalyzing the glucuronidation
of small planar phenols and amines, is expressed in a tissue- and inducer-dependent …
of small planar phenols and amines, is expressed in a tissue- and inducer-dependent …
Differential regulation of alternate UDP-glucuronosyltransferase 1A6 gene promoters by hepatic nuclear factor-1
DJ Auyeung, FK Kessler, JK Ritter - Toxicology and applied pharmacology, 2003 - Elsevier
UDP-glucuronosyltransferase 1A6 (UGT1A6) is a major UGT contributing to the glucuronidation
of small phenolic compounds. The gene for rat 1A6 is expressed using two promoters, a …
of small phenolic compounds. The gene for rat 1A6 is expressed using two promoters, a …
Picosecond optical pulse generation at gigahertz rates by direct modulation of a semiconductor laser
J AuYeung - Applied Physics Letters, 1981 - pubs.aip.org
A promising approach to increase the bit rate in pulse code modulation (CM) of semiconductor
lasers for fiber optic communication is to multiplex trains of ultrashort optical pulses. …
lasers for fiber optic communication is to multiplex trains of ultrashort optical pulses. …