Experimental genomics involves taking advantage of sequence information to investigate and
understand the workings of genes, cells and organisms. We have developed an approach …

… Giang and DJ Lockhart, unpublished results), although normalization and referencing … Giang
and DJ Lockhart, unpublished results). These amplification methods facilitate the possibility …

The human genome encodes approximately 100,000 different genes, and at least partial
sequence information for nearly all will be available soon. Sequence information alone, …

The functions of many open reading frames (ORFs) identified in genome-sequencing projects
are unknown. New, whole-genome approaches are required to systematically determine …

Progression through the eukaryotic cell cycle is known to be both regulated and accompanied
by periodic fluctuation in the expression levels of numerous genes. We report here the …

Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets
1 , 2 . The biological consequences of multi-kinase activity are poorly defined, and an …

Rapid access to genetic information is central to the revolution taking place in molecular
genetics. The simultaneous analysis of the entire human mitochondrial genome is described …

Kinase inhibitors show great promise as a new class of therapeutics. Here we describe an
efficient way to determine kinase inhibitor specificity by measuring binding of small molecules …

The unfolded protein response (UPR) regulates gene expression in response to stress in
the endoplasmic reticulum (ER). We determined the transcriptional scope of the UPR using …

The genomic sequence of the budding yeast Saccharomyces cerevisiae has been used to
design and synthesize high-density oligonucleotide arrays for monitoring the expression …