Aberrant Wnt/β-catenin signaling is widely implicated in numerous malignancies, including
cancers of the gastrointestinal tract. Dysregulation of signaling is traditionally attributed to …

In the absence of disease, the vasculature of the mammalian eye is quiescent, in part because
of the action of angiogenic inhibitors that prevent vessels from invading the cornea and …

In cancer, Wnt/β-catenin signaling is ubiquitously referred to as an “oncogenic” pathway that
promotes tumor progression. This review examines how the regulation and downstream …

The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to
intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of …

Thrombospondin-1 (TSP-1) is a naturally occurring inhibitor of angiogenesis that is able to
make normal endothelial cells unresponsive to a wide variety of inducers. Here we use both …

Controversy exists regarding the potential regenerative influences of incretin therapy on
pancreatic β-cells versus possible adverse pancreatic proliferative effects. Examination of …

… Copyright © 2021 Aguilera and Dawson. This is an open-access article distributed under
the terms of the Creative Commons Attribution License (CC BY). The use, distribution or …

Purpose Differences in cellular levels of histone modifications have predicted clinical outcome
in certain cancers. Here, we studied the prognostic and predictive value of three histone …

By tracking and ablating a specific CAF population, we find that a numerically minor CAF
subtype from a defined cell of origin plays unique roles in establishing the pancreatic tumor …

Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because
the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate …