User profiles for D. Bautista
Diana M BautistaUniversity of California Berkeley Verified email at berkeley.edu Cited by 21143 |
[HTML][HTML] Cellular and molecular mechanisms of pain
AI Basbaum, DM Bautista, G Scherrer, D Julius - Cell, 2009 - cell.com
The nervous system detects and interprets a wide range of thermal and mechanical stimuli,
as well as environmental and endogenous chemical irritants. When intense, these stimuli …
as well as environmental and endogenous chemical irritants. When intense, these stimuli …
TRPA1: A gatekeeper for inflammation
DM Bautista, M Pellegrino… - Annual review of …, 2013 - annualreviews.org
Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli,
tissue repair, and protective behaviors to prevent further damage and encourage healing…
tissue repair, and protective behaviors to prevent further damage and encourage healing…
Why we scratch an itch: the molecules, cells and circuits of itch
DM Bautista, SR Wilson, MA Hoon - Nature neuroscience, 2014 - nature.com
Itch is described as an irritating sensation that triggers a desire to scratch. However, this
definition hardly seems fitting for the millions of people who suffer from intractable itch. Indeed, …
definition hardly seems fitting for the millions of people who suffer from intractable itch. Indeed, …
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
Wasabi, horseradish and mustard owe their pungency to isothiocyanate compounds. Topical
application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory …
application of mustard oil (allyl isothiocyanate) to the skin activates underlying sensory …
[HTML][HTML] TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
DM Bautista, SE Jordt, T Nikai, PR Tsuruda, AJ Read… - Cell, 2006 - cell.com
TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic.
TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) …
TRPA1 has been proposed to function in diverse sensory processes, including thermal (cold) …
The menthol receptor TRPM8 is the principal detector of environmental cold
DM Bautista, J Siemens, JM Glazer, PR Tsuruda… - Nature, 2007 - nature.com
… d, Comparison of cold and heat sensitivity for wild type, TRPM8 -/- and TRPV1 -/- neurons.
For wild-type ganglia (grey bars) 4% of neurons were activated with a threshold of 12 C, 17% …
For wild-type ganglia (grey bars) 4% of neurons were activated with a threshold of 12 C, 17% …
TRPA1 mediates formalin-induced pain
…, J Mandel-Brehm, DM Bautista… - Proceedings of the …, 2007 - National Acad Sciences
The formalin model is widely used for evaluating the effects of analgesic compounds in
laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the …
laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; the …
Pungent products from garlic activate the sensory ion channel TRPA1
DM Bautista, P Movahed, A Hinman… - Proceedings of the …, 2005 - National Acad Sciences
Garlic belongs to the Allium family of plants that produce organosulfur compounds, such as
allicin and diallyl disulfide (DADS), which account for their pungency and spicy aroma. Many …
allicin and diallyl disulfide (DADS), which account for their pungency and spicy aroma. Many …
TRP channel activation by reversible covalent modification
…, H Chuang, DM Bautista, D Julius - Proceedings of the …, 2006 - National Acad Sciences
… (d) Calcium imaging of HEK293 cells transfected with TRPA1 shows robust responses to
NMM (20 μM). (e) Average traces from Fura-2 ratiometric imaging of 20 capsaicin-responsive …
NMM (20 μM). (e) Average traces from Fura-2 ratiometric imaging of 20 capsaicin-responsive …
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
…, J Siemens, S Materazzi, DM Bautista… - Proceedings of the …, 2007 - National Acad Sciences
TRPA1 is an excitatory ion channel expressed by a subpopulation of primary afferent
somatosensory neurons that contain substance P and calcitonin gene-related peptide. …
somatosensory neurons that contain substance P and calcitonin gene-related peptide. …