… d, Haplotype analysis of three kindred studied. All the patients have a common haplotype
(… d–e, P56S mutant does not colocalize either with Golgi apparatus (blue) or with the ER (red)…

… 2d. Because the individual PE and PPE proteins did not express well or fold, we conclude
that protein partnering is necessary for these functions. Such a codependent folding has been …

… d, NACore and SubNACore were aggregated in identical conditions and monitored by
turbidity. NACore begins to aggregate after 15 h while SubNACore forms no aggregates for up to …

… 221) with an optimized unit cell parameter of 19.39 Å (Figure 1D). The calculated PXRD
pattern of the calculated structure was shown to be coincident with the experimental PXRD …

… (D) Native nanoelectrospray mass spectrum of K11V-TR peak fractions from SEC-HPLC
reveals trimeric tandem-repeat cylindrin oligomers, confirming that the oligomeric complexes …

… Each oligomer possesses two rigid-body degrees of freedom, one translational (r) and one
rotational (ω), that are systematically sampled to identify (C)configurations with (D) a large …

… (D) Cartoon representation of mVDAC1 viewed perpendicular to the membrane plane (…
3 C and D) show that the interior of the pore has a higher density of positive versus negative …

Amyloid-beta (Aβ) aggregates are the main constituent of senile plaques, the histological
hallmark of Alzheimer’s disease. Aβ molecules form β-sheet containing structures that …

Membrane transporters that use energy stored in sodium gradients to drive nutrients into
cells constitute a major class of proteins. We report the crystal structure of a member of the …

Subcellular membraneless assemblies are a reinvigorated area of study in biology, with
spirited scientific discussions on the forces between the low-complexity protein domains within …