… The protein repertoire of Can 10 cells, which is close to that of the hepatocyte, especially for
claudins (D. Cassio and B. Grosse; unpublished data), means that they can be a useful tool …

… (Portions of this work have been published in abstract form [Cassio, D., M. Shanks, G. Ihrke,
… We labeled confluent WIF-B cultures with sNHS-LC-biotin (557 D) for 30 min at 4C, and then …

The development of nanotechnologies may lead to dissemination of potentially toxic
nanoparticles in the environment. Toxicology of these nano-sized particles is thus attracting …

Metal overload plays an important role in several diseases or intoxications, like in Wilson’s
disease, a major genetic disorder of copper metabolism in humans. To efficiently and …

Progressive familial intrahepatic cholestasis type 2 (PFIC2) is a result of mutations in ABCB11
encoding bile salt export pump (BSEP), the canalicular bile salt export pump of hepatocyte…

… (D) Elimination of Cu by the hepatocyte into the bile is decreased in WD patients as compared
to healthy individuals (N), causing Cu toxicosis. The main targets of toxic Cu are the brain …

BACKGROUND & AIMS: Progressive familial intrahepatic cholestasis type 2 (PFIC2) is due
to mutations in ABCB11 encoding the canalicular bile salt export pump (BSEP) of hepatocyte…

ABCG2 is involved in epithelial transport/barrier functions. Here, we have investigated its
ability to transport bile acids in liver and placenta. Cholylglycylamido fluorescein (CGamF) was …

Neonatal ichthyosis and sclerosing cholangitis (NISCH) syndrome is a liver disease caused
by mutations of CLDN1 encoding Claudin‐1, a tight‐junction (TJ) protein. In this syndrome, it …

Copper oxide nanoparticles (CuO-NP) were studied for their toxicity and mechanism of action
on hepatocytes (HepG2), in relation to Cu homeostasis disruption. Indeed, hepatocytes, in …