Collateral density, remodeling, and VEGF-A expression differ widely between mouse strains
D Chalothorn, JA Clayton, H Zhang… - Physiological …, 2007 - journals.physiology.org
Substantial variability exists in collateral density and ischemia-induced collateral growth
among species. To begin to probe the underlying mechanisms, which are unknown, we …
among species. To begin to probe the underlying mechanisms, which are unknown, we …
Vascular endothelial growth factor-A specifies formation of native collaterals and regulates collateral growth in ischemia
JA Clayton, D Chalothorn, JE Faber - Circulation research, 2008 - Am Heart Assoc
The density of native (preexisting) collaterals and their capacity to enlarge into large conduit
arteries in ischemia (arteriogenesis) are major determinants of the severity of tissue injury in …
arteries in ischemia (arteriogenesis) are major determinants of the severity of tissue injury in …
Formation and maturation of the native cerebral collateral circulation
D Chalothorn, JE Faber - Journal of molecular and cellular cardiology, 2010 - Elsevier
… 3d and h). The number of collaterals between the MCA and ACA trees increased 7-fold in …
5d, sum of black and white bars), similar to the small differences in the embryo (Figs. 3d and h)…
5d, sum of black and white bars), similar to the small differences in the embryo (Figs. 3d and h)…
Differences in the cellular localization and agonist-mediated internalization properties of the α1-adrenoceptor subtypes
D Chalothorn, DF McCune, SE Edelmann… - Molecular …, 2002 - ASPET
… D, bar graphs show the relative changes in the phospho-ERK1/2 signals for each receptor.
∗, significantly greater than the control level of ERK1/2 phosphorylation. †, statistically less …
∗, significantly greater than the control level of ERK1/2 phosphorylation. †, statistically less …
Strain-dependent variation in collateral circulatory function in mouse hindlimb
D Chalothorn, JE Faber - Physiological genomics, 2010 - journals.physiology.org
The extent (density and diameter) of the native (preexisting) collateral circulation in healthy
tissues and the capacity of collaterals to enlarge/remodel in obstructive arterial disease are …
tissues and the capacity of collaterals to enlarge/remodel in obstructive arterial disease are …
Catecholamines augment collateral vessel growth and angiogenesis in hindlimb ischemia
D Chalothorn, H Zhang, JA Clayton… - American Journal …, 2005 - journals.physiology.org
Catecholamine stimulation of α 1 -adrenoceptors exerts growth factor-like activity, mediated
by generation of reactive oxygen species, on arterial smooth muscle cells and adventitial …
by generation of reactive oxygen species, on arterial smooth muscle cells and adventitial …
Chloride intracellular channel-4 is a determinant of native collateral formation in skeletal muscle and brain
D Chalothorn, H Zhang, JE Smith, JC Edwards… - Circulation …, 2009 - Am Heart Assoc
The capacity of the collateral circulation to lessen injury in occlusive vascular disease
depends on the density and caliber of native (preexisting) collaterals, as well as their ability to …
depends on the density and caliber of native (preexisting) collaterals, as well as their ability to …
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle
H Zhang, D Chalothorn, LF Jackson, DC Lee… - Circulation …, 2004 - Am Heart Assoc
… Data in C and D are from images quantified by standard thresholding methods using Scion
… , using in-cell Western assays (Figure 7D), whereas agents alone had no effect (online data …
… , using in-cell Western assays (Figure 7D), whereas agents alone had no effect (online data …
[HTML][HTML] Hypotension, autonomic failure, and cardiac hypertrophy in transgenic mice overexpressing the α1B-adrenergic receptor
MJ Zuscik, D Chalothorn, D Hellard, C Deighan… - Journal of Biological …, 2001 - ASBMB
α 1 -Adrenergic receptors (α 1A , α 1B , and α 1D ) are regulators of systemic arterial blood
pressure and blood flow. Whereas vasoconstrictory action of the α 1A and α 1D subtypes is …
pressure and blood flow. Whereas vasoconstrictory action of the α 1A and α 1D subtypes is …
[HTML][HTML] The association between factor XI deficiency and the risk of bleeding, cardiovascular, and venous thromboembolic events
The objective of this study was to assess the relationship between factor XI (FXI) deficiency
and the risks of bleeding and cardiovascular (CV) events. We conducted a retrospective …
and the risks of bleeding and cardiovascular (CV) events. We conducted a retrospective …