Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
…, PH Van Der Graaf, J Arrowsmith, DE Feltner… - Drug discovery today, 2012 - Elsevier
In an effort to uncover systematic learnings that can be applied to improve compound survival,
an analysis was performed on data from Phase II decisions for 44 programs at Pfizer. It …
an analysis was performed on data from Phase II decisions for 44 programs at Pfizer. It …
Ca2+ channel α2δ ligands: novel modulators of neurotransmission
DJ Dooley, CP Taylor, S Donevan, D Feltner - Trends in pharmacological …, 2007 - cell.com
The term ‘Ca 2+ channel α 2 δ ligands' has recently been applied to an evolving drug class
that includes gabapentin (Neurontin ® ) and pregabalin (Lyrica ® ), and reflects significant …
that includes gabapentin (Neurontin ® ) and pregabalin (Lyrica ® ), and reflects significant …
How modeling and simulation have enhanced decision making in new drug development
…, A El-Kattan, CSW Li, JL Werth, DE Feltner… - … of pharmacokinetics and …, 2005 - Springer
The idea of model-based drug development championed by Lewis Sheiner, in which
pharmacostatistical models of drug efficacy and safety are developed from preclinical and available …
pharmacostatistical models of drug efficacy and safety are developed from preclinical and available …
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine (“Ecstasy”) in serotonin transporter-deficient mice
…, DL Murphy, AM Andrews, CH Wichems, D Feltner… - Molecular …, 1998 - ASPET
The sodium-dependent, high affinity serotonin [5-hydroxytryptamine (5-HT)] transporter (5-HTT)
provides the primary mechanism for inactivation of 5-HT after its release into the synaptic …
provides the primary mechanism for inactivation of 5-HT after its release into the synaptic …
Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli.
…, SH Phan, H Krutzsch, HJ Showell, DE Feltner… - Journal of Biological …, 1984 - Elsevier
Chemotactic factor-enriched butanol extracts from Escherichia coli culture filtrates were
fractionated and purified by high pressure liquid chromatography. The yield from individual …
fractionated and purified by high pressure liquid chromatography. The yield from individual …
Pregabalin for treatment of generalized anxiety disorder: a 4-week, multicenter, double-blind, placebo-controlled trial of pregabalin and alprazolam
K Rickels, MH Pollack, DE Feltner… - Archives of general …, 2005 - jamanetwork.com
… , the dosage was titrated to 450 mg/d on day 4; and for those … /d on day 7. Treatment with
alprazolam was initiated at 0.5 mg/d and was increased to 1.0 mg/d on day 4 and to 1.5 mg/d on …
alprazolam was initiated at 0.5 mg/d and was increased to 1.0 mg/d on day 4 and to 1.5 mg/d on …
Pregabalin in generalized anxiety disorder: a placebo-controlled trial
AC Pande, JG Crockatt, DE Feltner… - American Journal of …, 2003 - Am Psychiatric Assoc
OBJECTIVE: Current drug therapies for generalized anxiety disorder have limitations. In a
controlled trial, the novel agent pregabalin was studied for the treatment of patients with …
controlled trial, the novel agent pregabalin was studied for the treatment of patients with …
A randomized, double-blind, placebo-controlled, fixed-dose, multicenter study of pregabalin in patients with generalized anxiety disorder
DE Feltner, JG Crockatt, SJ Dubovsky… - Journal of clinical …, 2003 - journals.lww.com
… Few patients met criteria for a comorbid mood disorder in this study, and HAM-D scores at
… HAM-D, pregabalin 200 mg tid was more effective than placebo in improving HAM-D scores. …
… HAM-D, pregabalin 200 mg tid was more effective than placebo in improving HAM-D scores. …
Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy in patients with two copies of SMN2 (STR1VE): an open-label …
…, JM Kwon, CM Zaidman, M Schultz, DE Feltner… - The Lancet …, 2021 - thelancet.com
Background Spinal muscular atrophy type 1 is a motor neuron disorder resulting in death or
the need for permanent ventilation by age 2 years. We aimed to evaluate the safety and …
the need for permanent ventilation by age 2 years. We aimed to evaluate the safety and …
Vocal acoustic biomarkers of depression severity and treatment response
JC Mundt, AP Vogel, DE Feltner, WR Lenderking - Biological psychiatry, 2012 - Elsevier
… (2) L o g O d d s Re s p o n s e = − 2.45 + .06 ( B a s e l i n e T o t a l r e c o r d i n g l e
n g t h ) − 62.93 ( B a s e … Feltner is a former employee of Pfizer Inc. and owns Pfizer stock. Dr. …
n g t h ) − 62.93 ( B a s e … Feltner is a former employee of Pfizer Inc. and owns Pfizer stock. Dr. …