[HTML][HTML] The emerging role of FTY720 (Fingolimod) in cancer treatment

…, H Alshaker, C Cooper, M Winkler, D Pchejetski - Oncotarget, 2016 - ncbi.nlm.nih.gov
FTY720 (Fingolimod) is a clinically approved immunomodulating therapy for multiple sclerosis
that sequesters T-cells to lymph nodes through functional antagonism of sphingosine-1-…

[HTML][HTML] Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma

…, A Alfraidi, A Muhammad, M Winkler, D Pchejetski - Oncotarget, 2015 - ncbi.nlm.nih.gov
The prevalence of global obesity is increasing. Obesity is associated with general cancer-related
morbidity and mortality and is a known risk factor for development of specific cancers. A …

Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1

E Bonhoure, D Pchejetski, N Aouali, H Morjani… - Leukemia, 2006 - nature.com
We examined the involvement of sphingosine kinase-1, a critical regulator of the sphingolipid
balance, in susceptibility to antineoplastic agents of either sensitive or multidrug-resistant …

Oxidative stress–dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A–associated cardiac cell apoptosis

D Pchejetski, O Kunduzova, A Dayon, D Calise… - Circulation …, 2007 - Am Heart Assoc
The mitochondrial enzyme monoamine oxidase (MAO), its isoform MAO-A, plays a major role
in reactive oxygen species–dependent cardiomyocyte apoptosis and postischemic cardiac …

Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models

D Pchejetski, M Golzio, E Bonhoure, C Calvet… - Cancer research, 2005 - AACR
Systemic chemotherapy was considered of modest efficacy in prostate cancer until the recent
introduction of taxanes. We took advantage of the known differential effect of camptothecin …

Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1

D Pchejetski, C Foussal, C Alfarano… - European heart …, 2012 - academic.oup.com
… (D) Representative photomicrographs of cardiac fibroblasts pretreated with 100 nM apelin,
exposed to transforming growth factor-β for 48 h and stained with Sirius Red. (E) Quantitative …

FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1

D Pchejetski, T Bohler, L Brizuela, L Sauer, N Doumerc… - Cancer research, 2010 - AACR
… PC-3 (A–C) and DU145 (D) cells were treated with FTY720 at indicated concentrations
for the indicated times. A, viability of PC-3 cells was quantified by MTT reduction assay. B, …

Therapeutic potential of targeting SK1 in human cancers

…, S Ottaviani, S Srivats, T Böhler, D Pchejetski - Advances in cancer …, 2013 - Elsevier
Sphingosine kinase 1 (SK1) is a lipid enzyme with oncogenic properties that converts the
proapoptotic lipids ceramide and sphingosine into the antiapoptotic lipid sphingosine-1-…

Targeting the sphingolipid metabolism to defeat pancreatic cancer cell resistance to the chemotherapeutic gemcitabine drug

J Guillermet-Guibert, L Davenne, D Pchejetski… - Molecular cancer …, 2009 - AACR
Defeating pancreatic cancer resistance to the chemotherapeutic drug gemcitabine remains
a challenge to treat this deadly cancer. Targeting the sphingolipid metabolism for improving …

Chemosensitizing effects of sphingosine kinase-1 inhibition in prostate cancer cell and animal models

D Pchejetski, N Doumerc, M Golzio, M Naymark… - Molecular cancer …, 2008 - AACR
We have previously reported that, in prostate cancer, inhibition of the oncogenic
sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) pathway is a key element in …