CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization
S Liekens, D Schols, S Hatse - Current pharmaceutical design, 2010 - ingentaconnect.com
… These include derivatives like TE14011 and the N-terminally acetylated (Ac-TE) 14011, where
the basic amino acid residues have been replaced with D-Glu and/or Lcitrulline in order to …
the basic amino acid residues have been replaced with D-Glu and/or Lcitrulline in order to …
Antiviral agents active against human herpesviruses HHV‐6, HHV‐7 and HHV‐8
…, L Naesens, L De Bolle, D Schols… - Reviews in medical …, 2001 - Wiley Online Library
… Zhang Y, De Bolle L, Aquaro S, Van Lommel A, De Clercq E, Schols D. Productive
infection of primary macrophages with human herpesvirus type 7. J Virol 2001; 75: 10511–10514. …
infection of primary macrophages with human herpesvirus type 7. J Virol 2001; 75: 10511–10514. …
Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds
…, J Balzarini, M Baba, R Snoeck, D Schols… - Journal of virological …, 1988 - Elsevier
A rapid, sensitive and automated assay procedure was developed for the in vitro evaluation
of anti-HIV agents. An HTLV-I transformed T4-cell line, MT-4, which was previously shown …
of anti-HIV agents. An HTLV-I transformed T4-cell line, MT-4, which was previously shown …
Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives
R Pauwels, K Andries, J Desmyter, D Schols, MJ Kukla… - Nature, 1990 - nature.com
IN the search for compounds active against human immunodeficiency virus (HIV), we have
found that members of a novel series of tetrahydro-imidazo[4,5,1-jk][l,4]-benzodiazepin-2(1H)-…
found that members of a novel series of tetrahydro-imidazo[4,5,1-jk][l,4]-benzodiazepin-2(1H)-…
CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity
Astrocytes actively participate in synaptic integration by releasing transmitter (glutamate) via
a calcium-regulated, exocytosis-like process. Here we show that this process follows …
a calcium-regulated, exocytosis-like process. Here we show that this process follows …
[HTML][HTML] Algal lectins as potential HIV microbicide candidates
D Huskens, D Schols - Marine drugs, 2012 - mdpi.com
The development and use of topical microbicides potentially offers an additional strategy to
reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding …
reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding …
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor
GA Donzella, D Schols, SW Lin, JA Esté… - Nature medicine, 1998 - nature.com
… & Baltimore, D. Distinct modes of human immunodeficiency virus type 1 proviral latency
revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-…
revealed by superinfection of nonproductively infected cell lines with recombinant luciferase-…
Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4
D Schols, S Struyf, JV Damme, JA Esté… - The Journal of …, 1997 - rupress.org
… The biotinylated human MIP-1α and MIP-1β fluorokine TM kits were purchased from R &
D Systems Inc. The mAb, termed 12G5, reacts specifically with the human CXCR4 and was …
D Systems Inc. The mAb, termed 12G5, reacts specifically with the human CXCR4 and was …
[HTML][HTML] STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
…, W Chiu, P Leyssen, E Heylen, D Schols… - Nature …, 2020 - nature.com
… d Histopathological scoring of the lungs for all different mouse strains. Mice were sacrificed
on day 3 pi, and the lungs were stained with H&E and scored for signs of lung damage (…
on day 3 pi, and the lungs were stained with H&E and scored for signs of lung damage (…
[HTML][HTML] Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4
S Hatse, K Princen, G Bridger, E De Clercq, D Schols - FEBS letters, 2002 - Elsevier
This study was undertaken to demonstrate the unique specificity of the chemokine receptor
CXCR4 antagonist AMD3100. Calcium flux assays with selected chemokine/cell …
CXCR4 antagonist AMD3100. Calcium flux assays with selected chemokine/cell …