The functions of caveolae, the characteristic plasma membrane invaginations, remain debated.
Their abundance in cells experiencing mechanical stress led us to investigate their role …

Caveolae are abundant cell-surface organelles involved in lipid regulation and endocytosis.
We used comparative proteomics to identify PTRF (also called Cav-p60, Cavin) as a …

The clonogenic or colony formation assay is a widely used method to study the number and
size of cancer cell colonies that remain after irradiation or cytotoxic agent administration and …

Introduction Class I cytokines regulate key processes such as growth, lactation, hematopoiesis,
and immune function and contribute to oncogenesis. Although the extracellular domain …

Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose
expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance …

The structural elements encoding functional diversity among Ras GTPases are poorly
defined. The orientation of the G domain of H-ras with respect to the plane of the plasma …

Ras proteins regulate signal transduction processes that control cell growth and proliferation.
Their disregulation is a common cause of human tumors. Atomic level structural and …

The plasma membrane nanoscale distribution of H‐ras is regulated by guanine nucleotide
binding. To explore the structural basis of H‐ras membrane organization, we combined …

H-, N- and K-ras4B are lipid-anchored, peripheral membrane guanine nucleotide binding
proteins. Recent work has shown that Ras proteins are laterally segregated into non-…

The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor.
However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly …