Frequent gene amplification of the receptor-activated calcium-dependent chloride channel
TMEM16A (TAOS2 or ANO1) has been reported in several malignancies. However, its …

Recent advances in embedded three-dimensional (3D) bioprinting have expanded the
design space for fabricating geometrically complex tissue scaffolds using hydrogels with …

In tissue engineering, an unresolved challenge is how to build complex 3D scaffolds in order
to recreate the structure and function of human tissues and organs. Additive manufacturing …

When challenged by hypertonicity, dehydrated cells must recover their volume to survive.
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …

Three‐dimensional (3D) bioprinting is a promising technology to produce tissue‐like
structures, but a lack of diversity in bioinks is a major limitation. Ideally each cell type would be …

Purpose: Tumor metastasis is the leading cause of death in patients with cancer. However,
the mechanisms that underlie metastatic progression remain unclear. We examined …

To achieve organization and function, engineered tissues require a scaffold that supports
cell adhesion, alignment, growth, and differentiation. For skeletal muscle tissue engineering, …

The role that mechanical forces play in shaping the structure and function of the heart is critical
to understanding heart formation and the etiology of disease but is challenging to study in …

Three-dimensional (3D) bioprinting is a transformative technology for engineering tissues
for disease modeling and drug screening and building tissues and organs for repair, …

Soft tissue injuries such as volumetric muscle loss (VML) are often too large to heal normally
on their own, resulting in scar formation and functional deficits. Decellularized extracellular …