Cytotoxic properties of the eosinophil major basic protein

GJ Gleich, E Frigas, DA Loegering… - The Journal of …, 1979 - journals.aai.org
The eosinophil major basic protein (MBP) damages cells including those from organs whose
dysfunction is associated with eosinophil infiltration. Concentrations of MBP in the toxic …

Toxicity of Eosinophil Cationic Proteins for Guinea Pig Tracheal Epithelium In Vifr01

S Motojima, E Frigas, DA Loegering, GJ Gleich - Am Rev Respir Dis, 1989 - atsjournals.org
We tested the effects of four eosinophil granule cationic proteins: major basic protein (MBP),
eosinophil cationic protein (ECP), eosinophil peroxidase (EPO), and eosinophil-derived …

Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.

GJ Gleich, DA Loegering, MP Bell… - Proceedings of the …, 1986 - National Acad Sciences
Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) were isolated
from lysates of human eosinophil granules by gel filtration and ion exchange chromatography …

[HTML][HTML] An investigation of the cause of the eosinophilia–myalgia syndrome associated with tryptophan use

…, KE White, AN Mayeno, DA Loegering… - … England Journal of …, 1990 - Mass Medical Soc
Background. The eosinophilia—myalgia syndrome is a newly recognized illness that has
been associated with the consumption of tryptophan products. It is not known whether the …

Damage to Schistosomula of Schistosoma Mansoni Induced Directly by Eosinophil Major Basic Protein

…, GJ Gleich, DA Loegering, JR David - Journal of …, 1979 - journals.aai.org
Major basic protein (MBP) from both human and guinea pig eosinophils has been found to
damage schistosomula of Schistosoma mansoni at concentrations as low as 2 × 10 -5 M. This …

Ribonuclease activity associated with human eosinophil-derived neurotoxin and eosinophil cationic protein.

NR Slifman, DA Loegering, DJ McKean… - Journal of immunology …, 1986 - journals.aai.org
The eosinophil granule contains a series of basic proteins, including major basic protein,
eosinophil peroxidase, eosinophil-derived neurotoxin (EDN), and eosinophil cationic protein (…

Eosinophil granule proteins in peripheral blood granulocytes

…, SL Dunnette, DA Loegering… - Journal of leukocyte …, 1992 - Wiley Online Library
Eosinophils contain four principal cationic proteins, major basic protein (MBP), eosinophil‐derived
neurotoxin (EDN), eosinophil cationic protein (ECP), and eosinophil peroxidase (EPO)…

Purification of human eosinophil-derived neurotoxin.

…, SJ Ackerman, DA Loegering… - Proceedings of the …, 1981 - National Acad Sciences
Human and animal eosinophils contain a powerful neurotoxin that causes selective neuronal
and axonal damage to white matter of cerebellum and spinal cord of experimental animals …

In vitro and In vivo Antitumor Effects of the Dual Insulin-Like Growth Factor-I/Insulin Receptor Inhibitor, BMS-554417

P Haluska, JM Carboni, DA Loegering, FY Lee… - Cancer research, 2006 - AACR
The insulin-like growth factor receptor (IGF-IR) and insulin receptor are either overactivated
and/or overexpressed in a wide range of tumor types and contribute to tumorigenicity, …

Immunobiology of eosinophils

GJ Gleich, DA Loegering - Annual review of immunology, 1984 - annualreviews.org
The eosinophilic leukocyte was discovered by Paul Ehrlich in 1879 when he stained fixed
blood smears with aniline dyes (1). By the early part of this century a voluminous literature on …