[BOOK][B] Suprachiasmatic nucleus: the mind's clock

DC Klein, RY Moore, SM Reppert - 1991 - books.google.com
Based on a conference funded by the National Institutes of Health, this timely book is the most
up-to-date and definitive reference on the suprachiasmatic nucleus (SCN), the part of the …

Prostaglandins: stimulation of bone resorption in tissue culture

DC KLEIN, LG RAISZ - Endocrinology, 1970 - academic.oup.com
Prostaglandins (PG’s) stimulated resorption of fetal rat bone in 48–96 hr tissue culture. The
effects of several PG’s were compared to the stimulation of bone resorption caused by …

Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase

DC Klein, JL Weller - Science, 1970 - science.org
The activity of N-acetyltransferase in the rat pineal gland is more than 15 times higher at
night than during the day. This circadian rhythm persists in complete darkness, or in blinded …

Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity

RY Moore, DC Klein - Brain research, 1974 - Elsevier
The pineal enzyme, serotonin N-acetyltransferase, exhibits a circadian rhythm of activity
with nocturnal levels 15–30 times greater than those observed during a light period in the rat. …

Pineal N-acetyltransferase and hydroxyindole-O-methyl-transferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus

DC Klein, RY Moore - Brain research, 1979 - Elsevier
The visual pathway and central neural structures involved in the photic and endogenous
regulation of the activity of pineal N-acetyltransferase and hydroxyindole-O-methyltransferase …

Learned helplessness, depression, and the attribution of failure.

DC Klein, E Fencil-Morse… - Journal of personality and …, 1976 - psycnet.apa.org
40 depressed and 40 nondepressed (Beck Depression Inventory) college students received
solvable, unsolvable, or no discrimination problems. When later tested on a series of …

The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.

DC Klein, SL Coon, PH Roseboom… - Recent progress in …, 1997 - europepmc.org
A remarkably constant feature of vertebrate physiology is a daily rhythm of melatonin in the
circulation, which serves as the hormonal signal of the daily light/dark cycle: melatonin levels …

GCN5-related N-acetyltransferases: a structural overview

F Dyda, DC Klein, AB Hickman - Annual review of biophysics …, 2000 - annualreviews.org
▪ Abstract Hundreds of acetyltransferases exist. All use a common acetyl donor—acetyl
coenzyme A—and each exhibits remarkable specificity for acetyl acceptors, which include small …

[HTML][HTML] Arylalkylamine N-acetyltransferase:“the Timezyme”

DC Klein - Journal of biological chemistry, 2007 - ASBMB
Arylalkylamine N-acetyltransferase controls daily changes in melatonin production by the
pineal gland and thereby plays a unique role in biological timing in vertebrates. Arylalkylamine …

[HTML][HTML] Crystal structure of the 14-3-3ζ: serotonin N-acetyltransferase complex: a role for scaffolding in enzyme regulation

T Obsil, R Ghirlando, DC Klein, S Ganguly, F Dyda - Cell, 2001 - cell.com
Serotonin N-acetyltransferase (AANAT) controls the daily rhythm in melatonin synthesis.
When isolated from tissue, AANAT copurifies with isoforms ϵ and ζ of 14-3-3. We have …