Lactate boosts TLR4 signaling and NF-κB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation
DJ Samuvel, KP Sundararaj, A Nareika… - The Journal of …, 2009 - journals.aai.org
It has been shown that lactate induces insulin resistance. However, the underlying mechanisms
have not been well understood. Based on our observation that lactate augments LPS-…
have not been well understood. Based on our observation that lactate augments LPS-…
A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface …
DJ Samuvel, LD Jayanthi, NR Bhat… - Journal of …, 2005 - Soc Neuroscience
The serotonin transporter (SERT) is regulated by various signaling mechanisms that may
operate to maintain appropriate levels of synaptic serotonin (5-HT). We demonstrate that one of …
operate to maintain appropriate levels of synaptic serotonin (5-HT). We demonstrate that one of …
Modulation of group II metabotropic glutamate receptor signaling by chronic cocaine
…, DA Baker, H Shen, DJ Samuvel… - … of Pharmacology and …, 2002 - ASPET
Repeated cocaine produces enduring neuroadaptations in glutamate transmission in the
nucleus accumbens that are thought to contribute to addiction. Group II metabotropic glutamate …
nucleus accumbens that are thought to contribute to addiction. Group II metabotropic glutamate …
Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase
…, CB Zhu, JL McCauley, DJ Samuvel… - Proceedings of the …, 2005 - National Acad Sciences
Human serotonin [5-hydroxytryptamine (5-HT)] transporters (hSERT, 5HTT, and SLC6A4)
inactivate 5-HT after release and are prominent targets for therapeutic intervention in mood, …
inactivate 5-HT after release and are prominent targets for therapeutic intervention in mood, …
Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after …
EM Adkins, DJ Samuvel, JU Fog, J Eriksen… - Biochemistry, 2007 - ACS Publications
To investigate microdomain association of the dopamine transporter (DAT), we employed
FCS (fluorescence correlation spectroscopy) and FRAP (fluorescence recovery after …
FCS (fluorescence correlation spectroscopy) and FRAP (fluorescence recovery after …
[HTML][HTML] Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors
…, V Jaligam, M Oz, LD Jayanthi, DJ Samuvel… - Journal of biological …, 2007 - ASBMB
D 3 dopamine receptors are expressed by dopamine neurons and are implicated in the
modulation of presynaptic dopamine neurotransmission. The mechanisms underlying this …
modulation of presynaptic dopamine neurotransmission. The mechanisms underlying this …
[HTML][HTML] Regulated internalization and phosphorylation of the native norepinephrine transporter in response to phorbol esters: evidence for localization in lipid rafts …
LD Jayanthi, DJ Samuvel, S Ramamoorthy - Journal of Biological Chemistry, 2004 - ASBMB
The effects of norepinephrine in the brain and periphery are terminated primarily by active
reuptake of the catecholamine via cocaine- and amphetamine-sensitive norepinephrine …
reuptake of the catecholamine via cocaine- and amphetamine-sensitive norepinephrine …
[HTML][HTML] Interleukin-6 released from fibroblasts is essential for up-regulation of matrix metalloproteinase-1 expression by U937 macrophages in coculture: cross-talking …
KP Sundararaj, DJ Samuvel, Y Li, JJ Sanders… - Journal of biological …, 2009 - ASBMB
Matrix metalloproteinases (MMPs) play a key role in periodontal disease. Although it is
known that macrophages and fibroblasts are co-localized and express MMPs in the diseased …
known that macrophages and fibroblasts are co-localized and express MMPs in the diseased …
Evidence for biphasic effects of protein kinase C on serotonin transporter function, endocytosis, and phosphorylation
LD Jayanthi, DJ Samuvel, RD Blakely… - Molecular …, 2005 - ASPET
The serotonin transporter (SERT) regulates 5-hydroxytryptamine (serotonin) (5-HT)
neurotransmission and is a high-affinity target for antidepressants and psychostimulants. In the …
neurotransmission and is a high-affinity target for antidepressants and psychostimulants. In the …
GABA transmission in the nucleus accumbens is altered after withdrawal from repeated cocaine
…, H Shen, R Lake, DJ Samuvel… - Journal of …, 2003 - Soc Neuroscience
Repeated cocaine causes enduring changes in dopamine and glutamate transmission in
the nucleus accumbens, and dopamine and glutamate terminals synapse on GABAergic …
the nucleus accumbens, and dopamine and glutamate terminals synapse on GABAergic …