The RESOLUTE consortium: unlocking SLC transporters for drug discovery

…, A Müller-Fahrnow, V Pütter, D Zindel… - Nature reviews Drug …, 2020 - nature.com
The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and
produce data sets to de-orphanize transporters in the solute carrier protein (SLC) …

[HTML][HTML] An overview of cell-based assay platforms for the solute carrier family of transporters

…, M Wilhelm, M Wright Muelas, D Zindel… - Frontiers in …, 2021 - frontiersin.org
The solute carrier (SLC) superfamily represents the biggest family of transporters with important
roles in health and disease. Despite being attractive and druggable targets, the majority …

G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling

D Zindel, P Mensat, Z Homayed, F Charrier‐savournin… - FASEB Journal, 2021 - hal.science
The Hippo pathway is an evolutionarily conserved kinase cascade involved in the control of
tissue homeostasis, cellular differentiation, proliferation, and organ size, and is regulated by …

Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling

D Zindel, S Engel, AR Bottrill, JP Pin… - Biochemical …, 2016 - portlandpress.com
The parathyroid hormone receptor 1 (PTH1R) is a member of family B of G-protein-coupled
receptors (GPCRs), predominantly expressed in bone and kidney where it modulates …

Engineered hyperphosphorylation of the β2-adrenoceptor prolongs arrestin-3 binding and induces arrestin internalization

D Zindel, AJ Butcher, S Al-Sabah, P Lanzerstorfer… - Molecular …, 2015 - ASPET
G protein–coupled receptor phosphorylation plays a major role in receptor desensitization
and arrestin binding. It is, however, unclear how distinct receptor phosphorylation patterns …

HTRF® Total and Phospho-YAP (Ser127) Cellular Assays

D Zindel, C Vol, O Lecha, I Bequignon, M Bilgic… - The Hippo Pathway …, 2019 - Springer
The YAP protein is a co-transcription factor increasing the expression of genes involved in
cell proliferation and repressing the expression of genes important for cell differentiation Cell …

[PDF][PDF] Localization and Dynamics of Beta-Adrenergic Receptor Mediated EGFR Transactivation on Micro-Patterned Surfaces

P Lanzerstorfer, U Müller, D Zindel, O Höglinger… - Biophysical …, 2015 - cell.com
Recent evidence suggests that activation of G protein-coupled receptors (GPCR), eg the β-adrenergic
receptor (βAR), leads to transactivation of adjacent membrane receptors such as …

[PDF][PDF] Analysis of Receptor Tyrosine Kinase and G-Protein Coupled Receptor Signaling Dynamics on Micro-Structured Surfaces

…, Y Yoneyama, U Mueller, R Haselgruebler, D Zindel… - Biophysical …, 2016 - cell.com
Membrane-localized proteins are essential to transmit signals into the cell. An important
issue is the interaction of these proteins with cytosolic proteins. To quantify such often short-lived …

[PDF][PDF] Analysis of Receptor Tyrosine Kinase and G-Protein Coupled Receptor Signaling Dynamics on Micro-Structured Surfaces

P Lanzerstorfer, Y Yoneyama, F Hakuno, D Zindel… - Biophysical …, 2017 - cell.com
Membrane-localized proteins are essential to transmit signals into the cell. An important
issue is the interaction of these proteins with cytosolic proteins. To quantify such often short-lived …

The Hippo Pathway

A Hergovich - Springer
Over the past 15 years, the Hippo pathway has emerged as an essential regulator of organ
growth and tissue homeostasis. Beginning with Drosophila geneticists, who laid much of the …