The potential neuroprotective role of sex hormones in chronic neurodegenerative disorders
and acute brain ischemia following cardiac arrest and stroke is of a great therapeutic interest…

Pharmacological studies using bradykinin B 2 receptor antagonists suggest that bradykinin,
an early mediator of inflammation and the main metabolite of the kallikrein-kinin system, is …

Background Pretreatment with 17β-estradiol (E2) is profoundly neuroprotective in young
animals subjected to focal and global ischemia. However, whether E2 retains its …

Transient global ischemia induces selective, delayed neuronal death in the hippocampal
CA1 and delayed cognitive deficits. Estrogen treatment ameliorates hippocampal injury …

Reproductive success depends on a robust and appropriately timed preovulatory LH surge.
The LH surge, in turn, requires ovarian steroid modulation of GnRH neuron activation by the …

We previously demonstrated that the monoclonal antibody Mab6H8 raised against the second
extracellular loop of the β 2 -adrenoceptor (β 2 -AR) had an agonist-like activity, mediated …

IgG fractions of patients were screened for autoantibodies against the beta1- and beta2-adrenoceptors
and the M2 acetylcholine receptor by enzyme immunoassays and surface …

Female reproductive aging in rats is characterized by reduced gonadotropin releasing hormone
(GnRH) neuronal activation under estradiol positive feedback conditions and a delayed …

Monoclonal antibodies were produced against a peptide corresponding to the second
extracellular loop of the human β 2 -adrenoceptor. One of these monoclonals, inducing an agonist-…

Rapid, nongenomic actions of 17β‐oestradiol (E 2 ) on hypothalamic neurones that may be
relevant to reproductive function were described decades ago. The orphan G protein‐…