CATIONIC drugs of different types and structures (antihistaminics, antiarrhythmics, sedatives,
opiates, cytostatics and antibiotics, for example) are excreted in mammals by epithelial …

Variants of the SLC22A4 gene are associated with susceptibility to rheumatoid arthritis and
Crohn's disease. SLC22A4 codes for an integral membrane protein, OCTN1, that has been …

Catecholaminergic signaling regulates various physiological functions, such as blood
pressure 1 and is implicated in drug dependence, affective disorders and male aggressive …

The recently identified transport proteins organic cation transporter 1 (OCT1), OCT2, and
extraneuronal monoamine transporter (EMT) accept dopamine, noradrenaline, adrenaline, and …

The recently cloned apical renal transport system for organic cations (OCT2) exists in
dopamine-rich tissues such as kidney and some brain areas (Gründemann, D., Babin-Ebell, J., …

Ergothioneine (ET) is a unique natural antioxidant. We have examined the origin of ET in
zebrafish. There was virtually no ET, measured by LC–MS, in most tank vegetation (plant, …

Renal secretion of organic cations involves at least two distinct transporters, located in the
basolateral and apical membranes of proximal tubule cells. Whereas the basolateral …

… HEK 293 cells stably transfected with pcDNA3 OCT1 and pcDNA3 OCT3 constructs were
kindly provided by Dirk Gründemann and served as positive control. … Dirk Gründemann …

Preparative gel electrophoresis of double- stranded DNA usually includes staining the gel
with ethidium bromide followed by illumination with ultraviolet (UV-B) light. In this report, DNA …

Ergothioneine (ET) is a natural compound which humans and other vertebrates cannot
synthesize themselves; it must be absorbed from food in which it is distributed very unevenly. In …