The subepithelial intestinal myofibroblast is an important cell orchestrating many diverse
functions in the intestine and is involved in growth and repair, tumorigenesis, inflammation, and …

Over the past twenty years, thousands of physicians have come to depend on Yamada’s
Textbook of Gastroenterology. Its encyclopaedic discussion of the basic science underlying …

Human colonic epithelial cell renewal, proliferation, and differentiation are stringently
controlled by numerous regulatory pathways. To identify genetic programs of human colonic …

Background & Aims: A prominent role for inhibitory molecules PD-L1 and PD-L2 in
peripheral tolerance has been proposed. However, the phenotype and function of PD-L–expressing …

Context.—Myofibroblasts are distinct cells with characteristics of both smooth muscle cells
and fibroblasts. Through their ability to secrete cytokines, chemokines, prostaglandins, growth …

Objective Although both innate and adaptive responses to microbiota have been implicated
in the pathogenesis of IBD, it is still largely unknown how they are regulated during intestinal …

APPROXIMATELY 10% to 15% of the adult population or more than 20 million people in the
United States have gallstones. It is estimated that there are about 1 million newly diagnosed …

BACKGROUND & AIMS: Intestinal stem cells (ISCs) are regulated by the mesenchymal
environment via physical interaction and diffusible factors. We examined the role of Indian …

The human gastrointestinal mucosa is exposed to a diverse normal microflora and dietary
Ags and is a common site of entry for pathogens. The mucosal immune system must respond …

IL‐6 is a pleiotropic cytokine increased in CRC and known to directly promote tumor growth.
Colonic myofibroblasts/fibroblasts (CMFs or stromal cells) are CD90 + innate immune cells …