Semi-automated analysis of mouse skeletal muscle morphology and fiber-type composition
For years, distinctions between skeletal muscle fiber types were best visualized by myosin-ATPase
staining. More recently, immunohistochemical staining of myosin heavy chain (MyHC…
staining. More recently, immunohistochemical staining of myosin heavy chain (MyHC…
Venus fly trap domain of mGluR1 functions as a dominant negative against group I mGluR signaling
D Beqollari, PJ Kammermeier - Journal of neurophysiology, 2010 - journals.physiology.org
Metabotropic glutamate receptors (mGluRs) form covalently linked homodimers and contain
large, N-terminal extracellular ligand binding, “venus fly trap” (VFT) domains. These domains…
large, N-terminal extracellular ligand binding, “venus fly trap” (VFT) domains. These domains…
[HTML][HTML] Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to …
D Beqollari, CF Romberg, G Dobrowolny, M Martini… - Skeletal muscle, 2016 - Springer
Progressive impairment of CaV1.1 function in the skeletal muscle of mice expressing a
mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis | …
mutant type 1 Cu/Zn superoxide dismutase (G93A) linked to amyotrophic lateral sclerosis | …
The interaction between mGluR1 and the calcium channel Cav2. 1 preserves coupling in the presence of long Homer proteins
D Beqollari, PJ Kammermeier - Neuropharmacology, 2013 - Elsevier
Group I metabotropic glutamate receptors (mGluR1 and 5) are G protein coupled receptors
that regulate neuronal activity in a number of ways. Some of the most well studied functions …
that regulate neuronal activity in a number of ways. Some of the most well studied functions …
[HTML][HTML] Putative malignant hyperthermia mutation CaV1. 1-R174W is insufficient to trigger a fulminant response to halothane or confer heat stress intolerance
…, J Zheng, A Uryash, Y Dong, D Beqollari… - Journal of Biological …, 2023 - ASBMB
Malignant hyperthermia susceptibility (MHS) is an autosomal dominant pharmacogenetic
disorder that manifests as a hypermetabolic state when carriers are exposed to halogenated …
disorder that manifests as a hypermetabolic state when carriers are exposed to halogenated …
The mGlu4 receptor allosteric modulator N-phenyl-7-(hydroxyimino) cyclopropa [b] chromen-1a-carboxamide acts as a direct agonist at mGlu6 receptors
D Beqollari, PJ Kammermeier - European journal of pharmacology, 2008 - Elsevier
Effects of the mGlu 4 receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
(PHCCC) were tested on closely related mGlu6 receptors. …
(PHCCC) were tested on closely related mGlu6 receptors. …
Rem uncouples excitation–contraction coupling in adult skeletal muscle fibers
D Beqollari, CF Romberg, D Filipova, U Meza… - Journal of General …, 2015 - rupress.org
In skeletal muscle, excitation–contraction (EC) coupling requires depolarization-induced
conformational rearrangements in L-type Ca 2+ channel (Ca V 1.1) to be communicated to the …
conformational rearrangements in L-type Ca 2+ channel (Ca V 1.1) to be communicated to the …
Altered G-protein coupling in an mGluR6 point mutant associated with congenital stationary night blindness
D Beqollari, MJ Betzenhauser, PJ Kammermeier - Molecular pharmacology, 2009 - ASPET
The highly specialized metabotropic glutamate receptor type 6 (mGluR6) is postsynaptically
localized and expressed only in the dendrites of ON bipolar cells. Upon activation of …
localized and expressed only in the dendrites of ON bipolar cells. Upon activation of …
RGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubes
CF Romberg, D Beqollari, U Meza, RA Bannister - Channels, 2014 - Taylor & Francis
Three physiological functions have been described for the skeletal muscle 1,4-dihydropyridine
receptor (Ca V 1.1): (1) voltage-sensor for excitation-contraction (EC) coupling, (2) L-type …
receptor (Ca V 1.1): (1) voltage-sensor for excitation-contraction (EC) coupling, (2) L-type …
[HTML][HTML] A skeletal muscle L-type Ca2+ channel with a mutation in the selectivity filter (CaV1. 1 E1014K) conducts K+
D Beqollari, K Dockstader, RA Bannister - Journal of Biological Chemistry, 2018 - ASBMB
A glutamate-to-lysine substitution at position 1014 within the selectivity filter of the skeletal
muscle L-type Ca 2+ channel (Ca V 1.1) abolishes Ca 2+ flux through the channel pore. Mice …
muscle L-type Ca 2+ channel (Ca V 1.1) abolishes Ca 2+ flux through the channel pore. Mice …