A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
…, JP Sullivan, CR Faltynek, DS Krafte - Proceedings of the …, 2007 - National Acad Sciences
Activation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis
in neurons. Antisense oligonucleotide studies directed against Na v 1.8 have shown …
in neurons. Antisense oligonucleotide studies directed against Na v 1.8 have shown …
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels
…, S Santos, ML Chapman, DS Krafte… - Proceedings of the …, 2013 - National Acad Sciences
Voltage-gated sodium (Na v ) channels play a fundamental role in the generation and
propagation of electrical impulses in excitable cells. Here we describe two unique structurally …
propagation of electrical impulses in excitable cells. Here we describe two unique structurally …
A rat brain Na+ channel α subunit with novel gating properties
We have constructed a full-length rat brain Na+ channel a subunit cDNA that differs from the
previously reported a subunit of Noda et al. at 6 amino acid positions. Transcription of the …
previously reported a subunit of Noda et al. at 6 amino acid positions. Transcription of the …
Sodium channels and nociception: recent concepts and therapeutic opportunities
DS Krafte, AW Bannon - Current opinion in pharmacology, 2008 - Elsevier
Recent scientific advances have enhanced our understanding of the role voltage-gated
sodium channels play in pain sensation. Human data on Nav1.7 show that gain-of-function …
sodium channels play in pain sensation. Human data on Nav1.7 show that gain-of-function …
Discovery and Biological Evaluation of 5-Aryl-2-furfuramides, Potent and Selective Blockers of the Nav1.8 Sodium Channel with Efficacy in Models of Neuropathic …
…, J Liu, S Werness, CR Faltynek, DS Krafte… - Journal of medicinal …, 2008 - ACS Publications
Na v 1.8 (also known as PN3) is a tetrodotoxin-resistant (TTx-r) voltage-gated sodium
channel (VGSC) that is highly expressed on small diameter sensory neurons and has been …
channel (VGSC) that is highly expressed on small diameter sensory neurons and has been …
A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy
…, DS Krafte, MA Fox, GR Stewart, S Petrovski… - …, 2018 - Wiley Online Library
Objective Many previous studies of drug repurposing have relied on literature review followed
by evaluation of a limited number of candidate compounds. Here, we demonstrate the …
by evaluation of a limited number of candidate compounds. Here, we demonstrate the …
Synthesis and structure-activity relationships of 6-heterocyclic-substituted purines as inactivation modifiers of cardiac sodium channels
…, S Rumney, GM Pilling, DS Krafte… - Journal of medicinal …, 1995 - ACS Publications
Purine-based analogs of SDZ 211-500 (5) were prepared and evaluated as inactivation
modifiers of guinea pig or human cardiac sodium (Na) channelsexpressed in Xenopus oocytes. …
modifiers of guinea pig or human cardiac sodium (Na) channelsexpressed in Xenopus oocytes. …
A-887826 is a structurally novel, potent and voltage-dependent Nav1. 8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats
…, S Joshi, P Honore, CR Faltynek, DS Krafte… - …, 2010 - Elsevier
Activation of sodium channels is essential to action potential generation and propagation.
Recent genetic and pharmacological evidence indicates that activation of Na v 1.8 channels …
Recent genetic and pharmacological evidence indicates that activation of Na v 1.8 channels …
Direct activation of an inwardly rectifying potassium channel by arachidonic acid
Y Liu, D Liu, L Heath, DM Meyers, DS Krafte… - Molecular …, 2001 - ASPET
Arachidonic acid (AA) is an important constituent of membrane phospholipids and can be
liberated by activation of cellular phospholipases. AA modulates a variety of ion channels via …
liberated by activation of cellular phospholipases. AA modulates a variety of ion channels via …
Inactivation of cloned Na channels expressed in Xenopus oocytes.
This study investigates the inactivation properties of Na channels expressed in Xenopus
oocytes from two rat IIA Na channel cDNA clones differing by a single amino acid residue. …
oocytes from two rat IIA Na channel cDNA clones differing by a single amino acid residue. …