The GABA A receptors are the major inhibitory neurotransmitter receptors in mammalian
brain. Each isoform consists of five homologous or identical subunits surrounding a central …

… In this article, Erwin Sigel and Andreas Buhr discuss recent studies that have identified
amino acid residues that are thought to form the binding pocket for these compounds. These …

Background. Eating disorders in children and adolescents remain a serious cause of
morbidity and mortality in children, adolescents, and young adults. The working knowledge of …

Different combinations of cloned rat brain subunit isoforms of the GABAA receptor channel
were expressed in Xenopus oocytes. The voltage-clamp technique was then used to measure …

Ferns are the closest sister group to all seed plants, yet little is known about their genomes
other than that they are generally colossal. Here, we report on the genomes of Azolla …

The major isoform of the γ-aminobutyric acid type A (GABA A ) receptor is thought to be
composed of 2α 1 , 2β 2 , and 1γ 2 subunit(s), which surround the ion pore. Definite evidence for …

… More specifically, it may be expected that further residues will be described in loops E and F
… It is less clear for loops C and E. In the top a schematic representation of a GABAA receptor …

The search for novel anxiolytics devoid of undesirable side-effects typical of classical
benzodiazepines (BDZs) has been intense, and flavonoids, as a relative new class of ligands, have …

… negative allosteric modulators according to their intrinsic activity ( Sigel & Buhr, 1997 ). BZDs,
the … (e) Inhibition by apigenin of GABA-induced currents at recombinant α1β2γ2S GABA A …

The GABA A receptors are ligand-gated chloride channels. The subunit stoichiometry of the
receptors is controversial; four, five, or six subunits per receptor molecule have been …