Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia
Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurines, including 6-mercaptopurine
and 6-thioguanine. TPMT activity exhibits genetic polymorphism, with …
and 6-thioguanine. TPMT activity exhibits genetic polymorphism, with …
Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms
EY Krynetski, HL Tai, CR Yates… - Pharmacogenetics …, 1996 - journals.lww.com
Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurines such as
mercaptopurine and thioguanine. TPMT activity exhibits genetic polymorphism, with about 1 …
mercaptopurine and thioguanine. TPMT activity exhibits genetic polymorphism, with about 1 …
Genetic polymorphism of thiopurine S-methyltransferase: molecular mechanisms and clinical importance
EY Krynetski, WE Evans - Pharmacology, 2000 - karger.com
… 54 Tai HL, Fessing MY, Bonten EJ, Yanishevsky Y, d’Azzo A, Krynetski EY, Evans WE: Enhanced
proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in …
proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in …
Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance
CR Yates, EY Krynetski, T Loennechen… - Annals of internal …, 1997 - acpjournals.org
Background: Thiopurine S-methyltransferase (TPM) catalyzes the S-methylation (that is,
inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibits genetic …
inactivation) of mercaptopurine, azathioprine, and thioguanine and exhibits genetic …
Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus
…, JT Sandlund, RC Ribeiro, EY Krynetski… - Journal of the …, 1999 - academic.oup.com
BACKGROUND: Patients with acute lymphoblastic leukemia are often treated with 6-mercaptopurine,
and those with homozygous deficiency in thiopurine S-methyltransferase (TPMT) …
and those with homozygous deficiency in thiopurine S-methyltransferase (TPMT) …
Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine
…, F Tucci, N Kornegay, EY Krynetski… - Journal of Clinical …, 2001 - ascopubs.org
PURPOSE: To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in
patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and …
patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine (AZA), and …
Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.
HL Tai, EY Krynetski, CR Yates… - American journal of …, 1996 - ncbi.nlm.nih.gov
The autosomal recessive trait of thiopurine S-methytransferase (TPMT) deficiency is
associated with severe hematopoietic toxicity when patients are treated with standard doses of …
associated with severe hematopoietic toxicity when patients are treated with standard doses of …
Polymorphism of the Thiopurine S-Methyltransferase Gene in African-Americans
…, CH Pui, MV Relling, EY Krynetski… - Human molecular …, 1999 - academic.oup.com
The molecular basis for the genetic polymorphism of thiopurine S-methyltransferase (TPMT)
has been established for Caucasians, but it remains to be elucidated in African populations. …
has been established for Caucasians, but it remains to be elucidated in African populations. …
A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase.
EY Krynetski, JD Schuetz, AJ Galpin… - Proceedings of the …, 1995 - National Acad Sciences
Thiopurine S-methyltransferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase,
EC 2.1.1.67) activity exhibits genetic polymorphism, with approximately 0.33% of …
EC 2.1.1.67) activity exhibits genetic polymorphism, with approximately 0.33% of …
Enhanced proteolysis of thiopurine S-methyltransferase (TPMT) encoded by mutant alleles in humans (TPMT∗3A, TPMT∗2): Mechanisms for the genetic …
HL Tai, EY Krynetski, EG Schuetz… - Proceedings of the …, 1997 - National Acad Sciences
TPMT is a cytosolic enzyme that catalyzes the S-methylation of aromatic and heterocyclic
sulfhydryl compounds, including medications such as mercaptopurine and thioguanine. TPMT …
sulfhydryl compounds, including medications such as mercaptopurine and thioguanine. TPMT …