[HTML][HTML] Tissue-and isoform-specific kinetic behavior of the Na, K-ATPase

JS Munzer, SE Daly, EA Jewell-Motz, JB Lingrel… - Journal of Biological …, 1994 - Elsevier
The objective of this study has been to delineate the side-specific effects of Na+ and K+ on
the transport kinetics of tissue-specific Na/K pumps. Two experimental systems have been …

Site-directed mutagenesis of the sodium-potassium-ATPase: Consequences of substitutions of negatively-charged amino acids localized in the transmembrane …

EA Jewell-Motz, JB Lingrel - Biochemistry, 1993 - ACS Publications
Revised Manuscript Received August 24, 1993® abstract: Site-directed mutagenesis was
used to examinethe importance of five carboxyl-containing amino acids localized in the …

[HTML][HTML] G protein-coupled receptor kinase specificity for phosphorylation and desensitization of α2-adrenergic receptor subtypes

EA Jewell-Motz, SB Liggett - Journal of Biological Chemistry, 1996 - ASBMB
The α 2 -adrenergic receptor (α 2 AR) subtype α 2 C10 undergoes rapid agonist-promoted
desensitization which is due to phosphorylation of the receptor. One kinase that has been …

An Acidic Motif within the Third Intracellular Loop of the. alpha. 2C2 Adrenergic Receptor Is Required for Agonist-Promoted Phosphorylation and Desensitization

EA Jewell-Motz, SB Liggett - Biochemistry, 1995 - ACS Publications
Revised Manuscript Received July 10, 1995® abstract: The a. 2C2 adrenergic receptor
contains a highly acidic stretch of amino acids (EDEAEEEEEEEEEEEE) within the third …

Phosphorylation and functional desensitization of the α2A-adrenergic receptor by protein kinase C

M Liang, MG Eason, EA Jewell-Motz, MA Williams… - Molecular …, 1998 - ASPET
We have investigated the potential for protein kinase C (PKC) to phosphorylate and
desensitize the α 2A -adrenergic receptor (α 2A AR). In whole-cell phosphorylation studies, …

[HTML][HTML] α2A/α2C-adrenergic receptor third loop chimera show that agonist interaction with receptor subtype backbone establishes G protein-coupled receptor kinase …

EA Jewell-Motz, KM Small, CT Theiss… - Journal of Biological …, 2000 - ASBMB
The α 2A -adrenergic receptor (AR) undergoes rapid agonist-promoted desensitization due
to phosphorylation by G protein-coupled receptor kinases (GRKs) 2 and 3 at serines in the …

Agonist-Mediated Downregulation of Gαi via the α2-Adrenergic Receptor Is Targeted by Receptor-Gi Interaction and Is Independent of Receptor Signaling and …

EA Jewell-Motz, ET Donnelly, MG Eason… - Biochemistry, 1998 - ACS Publications
One mechanism of long-term agonist-promoted desensitization of α 2 AR function is
downregulation of the cellular levels of the α subunit of the inhibitory G protein, G i . In transfected …

Role of the Amino Terminus of the Third Intracellular Loop in Agonist-Promoted Downregulation of the α2A-Adrenergic Receptor

EA Jewell-Motz, ET Donnelly, MG Eason… - Biochemistry, 1997 - ACS Publications
A prominent feature of long-term regulation of the α 2A -adrenergic receptor (α 2A AR) is a
loss of cellular receptors over time (downregulation). The molecular determinants of …

Mutational analysis of Glu-327 of Na+-K+-ATPase reveals stimulation of86Rb+uptake by external K+

…, CL Johnson, EA Jewell-Motz… - … of Physiology-Cell …, 1997 - journals.physiology.org
A competition assay of 86 Rb + uptake in HeLa cells transfected with ouabain-resistant Na +
-K + -ATPase mutants revealed a stimulation of 86 Rb + uptake at low external …

Morphological and transcriptional evaluation of multiple facial cutaneous hyperpigmented spots

…, D Whittenbarger, EA JewellMotz… - Skin Health and …, 2022 - Wiley Online Library
Background Morphological characteristics of major facial hyperpigmented spots have been
well documented. However, detailed alterations of respective transcriptional profile for each …