Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond

P Rao, EE Knaus - Journal of pharmacy & …, 2008 - journals.library.ualberta.ca
… AG Habeeb, PNP Rao and EE Knaus. Design and synthesis of celecoxib and rofecoxib …
JM Uddin, PNP Rao and EE Knaus. Design and synthesis of novel celecoxib analogs as …

Novel Approaches for Designing 5'-O-Ester Prodrugs of 3'-Azido-2'3'-Dideoxythymidine (AZT)

K Parang, LI Wiebe, EE Knaus - Current medicinal chemistry, 2000 - ingentaconnect.com
3'-Azido-2'3'-dideoxythymidine (AZT, 1, zidovudine, RetrovirTM) is used to treat patients with
human immunodeficiency virus (HIV) infection. AZT, after conversion to AZT-5'-triphosphate (…

Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of sulfonamide and methylsulfonyl …

…, PN Praveen Rao, EE Knaus - Journal of Medicinal …, 2001 - ACS Publications
Celecoxib (13) and rofecoxib (17) analogues, in which the respective SO 2 NH 2 and SO 2
Me hydrogen-bonding pharmacophores were replaced by a dipolar azido bioisosteric …

Design and synthesis of 4, 5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity

…, PN Praveen Rao, EE Knaus - Journal of medicinal …, 2001 - ACS Publications
4,5-Diphenyl-4-isoxazolines (13a−k) possessing a variety of substituents (H, F, MeS, MeSO
2 ) at the para position of one of the phenyl rings were synthesized for evaluation as …

Syntheses, calcium channel Agonist− Antagonist modulation activities, and nitric oxide release studies of Nitrooxyalkyl 1, 4-Dihydro-2, 6-dimethyl-3-nitro-4-(2, 1, 3 …

R Shan, C Velazquez, EE Knaus - Journal of Medicinal Chemistry, 2004 - ACS Publications
A novel group of hybrid calcium channel (CC) modulators was prepared where the
isopropyl ester moiety of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)…

Synthesis of Celecoxib Analogues Possessing a N-Difluoromethyl-1,2-dihydropyrid-2-one 5-Lipoxygenase Pharmacophore: Biological Evaluation as Dual Inhibitors …

…, Y Dong, D Das, MR Suresh, EE Knaus - Journal of medicinal …, 2009 - ACS Publications
A novel class of 1-(4-methanesulfonylphenyl and 4-aminosulfonylphenyl)-5-[4-(1-difluoromethyl-1,2-dihydropyrid-2-one)]-3-trifluoromethyl-1H-pyrazole
hybrid cyclooxygenase-2 (COX-2…

Syntheses, calcium channel agonist-antagonist modulation activities, and voltage-clamp studies of isopropyl 1, 4-dihydro-2, 6-dimethyl-3-nitro-4-pyridinylpyridine-5 …

…, MW Wolowyk, SE Howlett, EE Knaus - Journal of medicinal …, 1995 - ACS Publications
A novel group of racemic isopropyl l, 4-dihydro-2, 6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate
isomers [(±)-12-14] were prepared using a modified Hantzsch reaction that …

Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective …

…, M Amini, H Li, AG Habeeb, EE Knaus - Journal of medicinal …, 2003 - ACS Publications
A group of 6-alkyl (alkoxy or alkylthio)-4-aryl-3-(4-methanesulfonylphenyl)pyran-2-ones (14a−v),
possessing either a H or F substituent at the para-position of the C-4 phenyl ring, were …

Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1, 2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide …

…, PN Praveen Rao, EE Knaus - Journal of medicinal …, 2005 - ACS Publications
Knaus. Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide
regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one …

Synthesis and biological evaluation of 1, 3-diphenylprop-2-en-1-ones possessing a methanesulfonamido or an azido pharmacophore as cyclooxygenase-1/-2 …

…, F Hakimion, FH Shirazi, PNP Rao, EE Knaus - Bioorganic & medicinal …, 2006 - Elsevier
A group of (E)-1,3-diphenylprop-2-en-1-one derivatives (chalcones) possessing a MeSO 2
NH, or N 3 , COX-2 pharmacophore at the para-position of the C-1 phenyl ring were …