β-Adrenergic agonists mediate enhancement of β1-adrenergic receptor N-terminal cleavage and stabilization in vivo and in vitro

AE Hakalahti, H Khan, MM Vierimaa, EH Pekkala… - Molecular …, 2013 - ASPET
The β 1 -adrenergic receptor (β 1 AR) is the predominant βAR in the heart and is the main
target for β-adrenergic antagonists, widely used in the treatment of cardiovascular diseases. …

[HTML][HTML] Site-specific O-glycosylation by polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) co-regulates β1-adrenergic receptor N-terminal …

CK Goth, HE Tuhkanen, H Khan, JJ Lackman… - Journal of Biological …, 2017 - ASBMB
The β 1 -adrenergic receptor (β 1 AR) is a G protein-coupled receptor (GPCR) and the
predominant adrenergic receptor subtype in the heart, where it mediates cardiac contractility and …

Lexical retrieval in discourse: An early indicator of Alzheimer's dementia

S Pekkala, D Wiener, JJ Himali, AS Beiser… - Clinical linguistics & …, 2013 - Taylor & Francis
We examined the progression of lexical-retrieval deficits in individuals with neuropathologically
determined Alzheimer’s disease (AD; n = 23) and a comparison group without criteria for …

[HTML][HTML] Laboratory Relationships between Adult Lifetime Reproductive Success and Fitness Surrogates in a Drosophila littoralis Population

N Pekkala, JS Kotiaho, M Puurtinen - PloS one, 2011 - journals.plos.org
The difficulties in measuring total fitness of individuals necessitate the use of fitness surrogates
in ecological and evolutionary studies. These surrogates can be different components of …

The benefits of interpopulation hybridization diminish with increasing divergence of small populations

N Pekkala, K E. Knott, JS Kotiaho… - Journal of …, 2012 - academic.oup.com
Interpopulation hybridization can increase the viability of small populations suffering from
inbreeding and genetic drift, but it can also result in outbreeding depression. The outcome of …

[HTML][HTML] Six-week endurance exercise alters gut metagenome that is not reflected in systemic metabolism in over-weight women

…, M Hollmén, L Elo, G D'Auria, S Pekkala - Frontiers in …, 2018 - frontiersin.org
Recent studies suggest that exercise alters the gut microbiome. We determined whether six-weeks
endurance exercise, without changing diet, affected the gut metagenome and …

[HTML][HTML] Development of a late-life dementia prediction index with supervised machine learning in the population-based CAIDE study

T Pekkala, A Hall, J Lötjönen, J Mattila… - Journal of …, 2017 - content.iospress.com
Background and objective: This study aimed to develop a late-life dementia prediction model
using a novel validated supervised machine learning method, the Disease State Index (DSI…

[HTML][HTML] What's in it for me and you? Exploring managerial perceptions of employees' work-related social media use

K Pekkala, T Auvinen, P Sajasalo… - Employee Relations: The …, 2022 - emerald.com
Purpose This study focuses on managers' perceptions of employees' communicative role in
social media, and explores the changes in the contractual nature of employment relations in …

[HTML][HTML] Gut microbiota, microbial metabolites and human physical performance

S Lensu, S Pekkala - Metabolites, 2021 - mdpi.com
… Satu Pekkala was financially supported by the Academy of Finland Researcher fellowship
(grant ID 308042). Sanna Lensu has financial support from the projects funded by the …

[PDF][PDF] The chromian marbles of Kittilä, Finnish Lapland

Y Pekkala, K Puustinen - Bull. geol. Soc. Fin, 1978 - scholar.archive.org
The investigated area is located about 130 km north of Rovaniemi (Fig. 1) and some 15 km
east-northeast of the village of Kittilä in Finnish Lapland. This paper describes the brightly …