PPARγ signaling and emerging opportunities for improved therapeutics
S Wang, EJ Dougherty, RL Danner - Pharmacological Research, 2016 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated nuclear
receptor that regulates glucose and lipid metabolism, endothelial function and inflammation. …
receptor that regulates glucose and lipid metabolism, endothelial function and inflammation. …
An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers
EJ Dougherty - Advances in Skin & Wound Care, 2008 - journals.lww.com
OBJECTIVE: A cost-effectiveness analysis compared the potential economic benefit of an
autologous, platelet-rich plasma (PRP) gel to alternative therapies in treating nonhealing …
autologous, platelet-rich plasma (PRP) gel to alternative therapies in treating nonhealing …
[HTML][HTML] Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance
…, DG Hunter, JS Soul, A Newlin, LJ Sabol, EJ Doherty… - Cell, 2010 - cell.com
We report that eight heterozygous missense mutations in TUBB3, encoding the neuron-specific
β-tubulin isotype III, result in a spectrum of human nervous system disorders that we now …
β-tubulin isotype III, result in a spectrum of human nervous system disorders that we now …
Health status of adults with congenital adrenal hyperplasia: a cohort study of 203 patients
Context: No consensus exists for management of adults with congenital adrenal hyperplasia
(CAH) due to a paucity of data from cohorts of meaningful size. Objective: Our objective was …
(CAH) due to a paucity of data from cohorts of meaningful size. Objective: Our objective was …
[HTML][HTML] Interdisciplinary views of fNIRS: Current advancements, equity challenges, and an agenda for future needs of a diverse fNIRS research community
Functional Near-Infrared Spectroscopy (fNIRS) is an innovative and promising neuroimaging
modality for studying brain activity in real-world environments. While fNIRS has seen rapid …
modality for studying brain activity in real-world environments. While fNIRS has seen rapid …
Protection of encapsulated human islets implanted without immunosuppression in patients with type I or type II diabetes and in nondiabetic control subjects
…, BJ Olack, PP Latta, OD Hegre, EJ Doherty… - Diabetes, 1994 - Am Diabetes Assoc
Human islets were macroencapsulated in permselective hollow fiber membrane devices
and successfully allotransplanted subcutaneously with > 90% viability after 2 weeks in situ. …
and successfully allotransplanted subcutaneously with > 90% viability after 2 weeks in situ. …
[HTML][HTML] Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm …
TTLL5/STAMP (tubulin tyrosine ligase-like family member 5) has multiple activities in cells.
TTLL5 is one of 13 TTLLs, has polyglutamylation activity, augments the activity of p160 …
TTLL5 is one of 13 TTLLs, has polyglutamylation activity, augments the activity of p160 …
[HTML][HTML] G protein-coupled receptor 40 (GPR40) and peroxisome proliferator-activated receptor γ (PPARγ): an integrated two-receptor signaling pathway
S Wang, KS Awad, JM Elinoff, EJ Dougherty… - Journal of Biological …, 2015 - ASBMB
Peroxisome proliferator-activated receptor γ (PPARγ) ligands have been widely used to treat
type 2 diabetes mellitus. However, knowledge of PPARγ signaling remains incomplete. In …
type 2 diabetes mellitus. However, knowledge of PPARγ signaling remains incomplete. In …
Type I interferon activation and endothelial dysfunction in caveolin-1 insufficiency-associated pulmonary arterial hypertension
S Gairhe, KS Awad, EJ Dougherty… - Proceedings of the …, 2021 - National Acad Sciences
Interferonopathies, interferon (IFN)-α/β therapy, and caveolin-1 (CAV1) loss-of-function
have all been associated with pulmonary arterial hypertension (PAH). Here, CAV1-silenced …
have all been associated with pulmonary arterial hypertension (PAH). Here, CAV1-silenced …
[HTML][HTML] CFEOM3: a new extraocular congenital fibrosis syndrome that maps to 16q24. 2-q24. 3
EJ Doherty, ME Macy, SM Wang… - … & visual science, 1999 - arvojournals.org
purpose. To define the clinical characteristics and determine the gene localization for a
previously undescribed form of congenital fibrosis of the extraocular muscles (CFEOM), referred …
previously undescribed form of congenital fibrosis of the extraocular muscles (CFEOM), referred …