Role of ABL family kinases in cancer: from leukaemia to solid tumours

EK Greuber, P Smith-Pearson, J Wang… - Nature Reviews …, 2013 - nature.com
The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces diverse
extracellular signals to protein networks that control proliferation, survival, migration and …

[HTML][HTML] Abl kinases are required for invadopodia formation and chemokine-induced invasion

PS Smith-Pearson, EK Greuber, G Yogalingam… - Journal of Biological …, 2010 - ASBMB
The Abl tyrosine kinases, Abl and Arg, play a role in the regulation of the actin cytoskeleton
by modulating cell-cell adhesion and cell motility. Deregulation of both the actin cytoskeleton …

Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages

EK Greuber, AM Pendergast - The Journal of Immunology, 2012 - journals.aai.org
Phagocytosis of Ab-coated pathogens is mediated through FcγRs, which activate intracellular
signaling pathways to drive actin cytoskeletal rearrangements. Abl and Arg define a family …

[HTML][HTML] Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific …

BW Jones, GJ Song, EK Greuber, PM Hinkle - Journal of biological …, 2007 - ASBMB
To study phosphorylation of the endogenous type I thyrotropin-releasing hormone receptor
in the anterior pituitary, we generated phosphosite-specific polyclonal antibodies. The major …

Role of helix 8 of the thyrotropin-releasing hormone receptor in phosphorylation by G protein-coupled receptor kinase

…, BW Jones, PN Tran, LB Cook, EK Greuber… - Molecular …, 2010 - ASPET
The thyrotropin-releasing hormone (TRH) receptor undergoes rapid and extensive agonist-dependent
phosphorylation attributable to G protein-coupled receptor (GPCR) kinases (GRKs…

[PDF][PDF] Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity

EK Greuber - 2013 - dukespace.lib.duke.edu
The Abl family of protein tyrosine kinases regulates diverse cellular processes by coordinating
cytoskeletal rearrangements. Recent data indicate that pharmacological inhibition of Abl …

Chronic myeloid leukemia and pregnancy:“Per Aspera Ad Astra”

E Abruzzese, MM Trawinska, P de Fabritiis - Clinical Lymphoma Myeloma …, 2021 - Elsevier
Introduction Chronic myeloid leukemia (CML) has evolved in the past 20 years from an
invariably fatal disease to a long-lasting, chronic disorder that can be treated with different …

[HTML][HTML] Identification of a novel SEPT9-ABL1 fusion gene in a patient with T-cell prolymphocytic leukemia

R Suzuki, H Matsushita, H Kawai, H Matsuzawa… - Leukemia Research …, 2014 - Elsevier
T-cell prolymphocytic leukemia (T-PLL), a rare type of peripheral T-cell leukemia, is characterized
by marked splenomegaly with rapidly progressive lymphocytosis and a poor prognosis…

The emerging role of ABL kinases in solid tumors

J Wang, AM Pendergast - Trends in cancer, 2015 - cell.com
The Abelson (ABL) tyrosine kinases have been identified as drivers of leukemia in mice and
humans. Emerging data demonstrate a role for the ABL family kinases, ABL1 and ABL2, in …

[HTML][HTML] Enterolobium contortisiliquum trypsin inhibitor (EcTI), a plant proteinase inhibitor, decreases in vitro cell adhesion and invasion by inhibition of Src protein …

CAA De Paula, VJ Coulson-Thomas, JG Ferreira… - Journal of Biological …, 2012 - ASBMB
Tumor cell invasion is vital for cancer progression and metastasis. Adhesion, migration, and
degradation of the extracellular matrix are important events involved in the establishment of …