Phorbol esters and neurotransmitter release: more than just protein kinase C?

EM Silinsky, TJ Searl - British journal of pharmacology, 2003 - Wiley Online Library
This review focuses on the effects of phorbol esters and the role of phorbol ester receptors
in the secretion of neurotransmitter substances. We begin with a brief background on the …

On the association between transmitter secretion and the release of adenine nucleotides from mammalian motor nerve terminals.

EM Silinsky - The Journal of physiology, 1975 - Wiley Online Library
SILINSKY stimulation period made after 20 min of rest. During the first three stimuli, the
compound map is reduced to an epp which is maintained only for three subsequent stimuli …

The biophysical pharmacology of calcium-dependent acetylcholine secretion

EM Silinsky - Pharmacological reviews, 1985 - scholars.northwestern.edu
This review is principally concerned with the release of the neurotransmitter, acetylcholine (ACh)
as detected by electrophysiological recordings at the skeletal neuromuscular junction. …

ATP released together with acetylcholine as the mediator of neuromuscular depression at frog motor nerve endings.

RS Redman, EM Silinsky - The Journal of Physiology, 1994 - Wiley Online Library
1. The hypothesis that ATP released by presynaptic stimulation is hydrolysed to adenosine
and mediates prejunctional neuromuscular depression was tested at vertebrate …

On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve endings.

EM Silinsky - The Journal of Physiology, 1984 - Wiley Online Library
The process by which adenosine receptor agonists inhibit the evoked release of acetylcholine
(ACh) was studied at motor nerve endings to frog skeletal muscle. Adenosine and 2‐…

Synchronous release of ATP and neurotransmitter within milliseconds of a motor nerve impulse in the frog.

EM Silinsky, RS Redman - The Journal of Physiology, 1996 - Wiley Online Library
1. It has been suggested that ATP is released together with the neurotransmitter acetylcholine
(ACh) and, after hydrolysis to adenosine, is the primary physiological mediator of …

ATP mediates excitatory synaptic transmission in mammalian neurones

EM Silinsky, V Gerzanich, SM Vanner - 1992 - Wiley Online Library
Adenosine 5′‐triphosphate (ATP, 0.1–100 μm), produced inward currents in patch‐clamped
coeliac neurones from guinea‐pig when studied in either the whole cell configuration or in …

Biological sciences: Release of ATP from rat motor nerve terminals

EM Silinsky, JI Hubbard - Nature, 1973 - nature.com
INVESTIGATION of the adrenal medulla 1,2 and the Torpedo electroplax 3 suggested that
ATP plays some part in the storage and release of chemical transmitters. The fluid bathing …

Mutual occlusion of P2X ATP receptors and nicotinic receptors on sympathetic neurons of the guinea‐pig

TJ Searl, RS Redman, EM Silinsky - The Journal of physiology, 1998 - Wiley Online Library
1 The interaction of ion channels activated by nicotinic receptor agonists with ion channels
gated by extracellular ATP (ie P2X receptors) was studied on sympathetic neurons acutely …

Some effects of 5‐hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea‐pig small intestine.

GD Hirst, EM Silinsky - The Journal of Physiology, 1975 - Wiley Online Library
… GDS HIRST AND EM SILINSKY The discharge of action potentials could be prevented by
passing hyperpolarizing current through the recording electrode (Fig. 1). These excitatory …