How antibiotic-producing organisms avoid suicide

E Cundliffe - Annual review of microbiology, 1989 - annualreviews.org
… gentamicin sensitive ribosomes (E. Cundliffe, unpublished data). This type of AAC activity
was first found in E. coli (34), and it was the fifth distinctive AAC(3) activity to be characterized. …

Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins

E Cundliffe, M Cannon… - Proceedings of the …, 1974 - National Acad Sciences
… (E. Cundliffe, unpublished data). Accordingly, we conclude that those trichothecenes which
cause breakdown of polyribosomes do so by inhibiting polypeptide chain initiation in a highly …

Avoidance of suicide in antibiotic-producing microbes

E Cundliffe, AL Demain - Journal of Industrial Microbiology and …, 2010 - academic.oup.com
… Beauclerk and E. Cundliffe, unpublished data; reported in [31]) and also in S. lividans
harbouring the kmr gene (also referred to as kan), originally isolated from S. kanamyceticus [155]. …

Site of action of a ribosomal RNA methylase responsible for resistance to erythromycin and other antibiotics.

R Skinner, E Cundliffe, FJ Schmidt - The Journal of biological …, 1983 - europepmc.org
The enzyme which confers resistance to erythromycin in the producing organism Streptomyces
erythraeus dimethylates a single adenine residue in Bacillus stearothermophilus 23 S …

Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides

AAD Beauclerk, E Cundliffe - Journal of molecular biology, 1987 - Elsevier
… lividans TSK412 were used to methylate 30 S ribosomal subunits from E’. coli. This was
done because it was intended subsequently to locate the methylated product(s) within the …

Inhibition of initiation, elongation, and termination of eukaryotic protein synthesis by trichothecene fungal toxins

E Cundliffe, JE Davies - Antimicrobial Agents and Chemotherapy, 1977 - Am Soc Microbiol
The 12,13-epoxytrichothecenes, specific inhibitors of protein synthesis in eukaryotes, can
be subdivided further in terms of their mode of action. In addition to the I-type (initiation …

Bacterial protein synthesis: the effects of antibiotics

E Cundliffe, K McQuillen - Journal of molecular biology, 1967 - Elsevier
Puromycin induced the release of nascent peptides from ribosomes. We have studied this
effect in vivo using protoplasts of Bacillus megaterium. Chloramphenicol, erythromycin and …

The antibiotic micrococcin is a potent inhibitor of growth and protein synthesis in the malaria parasite

MJ Rogers, E Cundliffe… - Antimicrobial agents and …, 1998 - Am Soc Microbiol
Cundliffe E. Recognition sites for antibiotics within rRNA The ribosome: structure, function
and evolution. Hill WE, Moore PB, Dahlberg A., Schlessinger D., Garrett RA, and Warner JR …

Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.

J Thompson, F Schmidt, E Cundliffe - The Journal of Biological …, 1982 - europepmc.org
A methylase enzyme, responsible for autoimmunity in the thiostrepton producer
Streptomyces azureus, renders ribosomes completely resistant to thiostrepton. This RNA …

[PDF][PDF] Impact of thioesterase activity on tylosin biosynthesis in Streptomyces fradiae

AR Butler, N Bate, E Cundliffe - Chemistry & biology, 1999 - cell.com
… Because the putative product of e;ryA 0$5 was clearly unable to duplicate the function(s) of
the PKS … Antibiotic resistance cassettes derived from the R interposon for use in E. co/i and …