Cytokine production in the brain following closed head injury: dexanabinol (HU-211) is a novel TNF-α inhibitor and an effective neuroprotectant
E Shohami, R Gallily, R Mechoulam, R Bass… - Journal of …, 1997 - Elsevier
Traumatic brain injury triggers a cascade of events resulting in delayed edema, necrosis and
impaired function. Harmful mediators are accumulating in the brain after injury and recently, …
impaired function. Harmful mediators are accumulating in the brain after injury and recently, …
Cerebral ischemia and trauma—different etiologies yet similar mechanisms: neuroprotective opportunities
RR Leker, E Shohami - Brain Research Reviews, 2002 - Elsevier
Cerebral ischemia leads to brain damage caused by pathogenetic mechanisms that are
also activated by neurotrauma. These mechanisms include among others excitotoxicity, over …
also activated by neurotrauma. These mechanisms include among others excitotoxicity, over …
Dual role of tumor necrosis factor alpha in brain injury
E Shohami, I Ginis, JM Hallenbeck - Cytokine & growth factor reviews, 1999 - Elsevier
… In a model of closed head injury in mice, it has also been shown (unpublished data Shohami,
Jerusalem) that significant reduction of edema and of BBB disruption could be achieved …
Jerusalem) that significant reduction of edema and of BBB disruption could be achieved …
An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
…, L Hanuš, A Breuer, R Mechoulam, E Shohami - Nature, 2001 - nature.com
Traumatic brain injury triggers the accumulation of harmful mediators that may lead to secondary
damage 1 , 2 . Protective mechanisms to attenuate damage are also set in motion 2 . 2-…
damage 1 , 2 . Protective mechanisms to attenuate damage are also set in motion 2 . 2-…
Peripheral cannabinoid receptor, CB2, regulates bone mass
…, M Attar-Namdar, V Kram, E Shohami… - Proceedings of the …, 2006 - National Acad Sciences
… 7 D and E). Together these data indicate that the low bone mass in CB2 –/– mice is
associated with high bone turnover, as observed, for example, in postmenopausal osteoporosis, …
associated with high bone turnover, as observed, for example, in postmenopausal osteoporosis, …
Mouse closed head injury model induced by a weight-drop device
…, KM Beauchamp, SJ Morgan, WR Smith, E Shohami - Nature protocols, 2009 - nature.com
… (e) The mobile platform allows for optimization of the trauma impact location on the mouse
… (e and f) After activation of the pedal, the rod is being released from its securing mechanism …
… (e and f) After activation of the pedal, the rod is being released from its securing mechanism …
Rapamycin is a neuroprotective treatment for traumatic brain injury
S Erlich, A Alexandrovich, E Shohami… - Neurobiology of …, 2007 - Elsevier
The mammalian target of rapamycin, commonly known as mTOR, is a serine/threonine kinase
that regulates translation and cell division. mTOR integrates input from multiple upstream …
that regulates translation and cell division. mTOR integrates input from multiple upstream …
Closed head injury triggers early production of TNFα and IL-6 by brain tissue
E Shohami, M Novikov, R Bass… - Journal of Cerebral …, 1994 - journals.sagepub.com
… -HETE), and at 24 h, mainly prostaglandin E 2 . The present study was designed to test whether
… Priming for enhanced release of tumor necrosis factor and prostaglandin E 2 . J Immunol …
… Priming for enhanced release of tumor necrosis factor and prostaglandin E 2 . J Immunol …
An experimental model of closed head injury in mice: pathophysiology, histopathology, and cognitive deficits
…, M WEINSTOCK, E SHOHAMI - Journal of …, 1996 - liebertpub.com
The present study describes the characterization of an experimental model of closed head
injury (CHI) in the mouse. This model is a modification of a setup described and used …
injury (CHI) in the mouse. This model is a modification of a setup described and used …
[PDF][PDF] CCR5 is a therapeutic target for recovery after stroke and traumatic brain injury
… (D and E) Animals with neuronal knockdown of CCR5 (shCCR5AAV) show improved motor
performances in gridwalk (D) and cylinder (E) tests at early and late time points after stroke. …
performances in gridwalk (D) and cylinder (E) tests at early and late time points after stroke. …