ATP functions as a fast neurotransmitter through the specific activation of a family of ligand-gated
ion channels termed P2X receptors. In this report, six distinct recombinant P2X receptor …

Nociceptive neurons in the dorsal root ganglia (DRG) are activated by extracellular ATP,
implicating P2X receptors as potential mediators of painful stimuli. However, the P2X receptor …

P2X receptors are a family of ATP-gated ion channels. Four cDNAs with a high degree of
homology to the rat P2X 2 receptor were isolated from human pituitary and pancreas RNA. …

DNA microarrays enable users to obtain information on differences in transcript abundance
on a massively parallel scale. Recently, however, data analyses have revealed potential …

The α 7 neuronal nicotinic acetylcholine receptor subtype forms a Ca 2+ -permeable
homooligomeric ion channel sensitive to α-bungarotoxin in Xenopus oocytes. In this study, we have …

TNP-ATP has become widely recognized as a potent and selective P2X receptor antagonist,
and is currently being used to discriminate between subtypes of P2X receptors in a variety …

Background DNA microarrays are now routinely used to monitor the transcript levels of
thousands of genes simultaneously. However, the array fabrication method, hybridization …

Partial cDNA clones generated by RT-PCR were used as probes to clone the cDNAs encoding
the human α4 and β2 neuronal nicotinic acetylcholine receptor (nAChR) subunits. The 2.1…

Bone repair consists of inflammation, intramembranous ossification, chondrogenesis,
endochondral ossification, and remodeling. To better understand the translational regulation of …

TP508 is a synthetic 23-amino acid peptide representing a receptor-binding domain of human
thrombin. We have previously shown that a single injection of TP508 accelerates fracture …