BRAFV600E alterations are prevalent across multiple tumors. Here we present final efficacy
and safety results of a phase 2 basket trial of dabrafenib (BRAF kinase inhibitor) plus …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

Background BRAF V600 mutations occur in various nonmelanoma cancers. We undertook
a histology-independent phase 2 “basket” study of vemurafenib in BRAF V600 mutation–…

Hurst, TP, Fernandez, ER, and Mathis, JT 2013. Effects of ocean acidification on hatch size
and larval growth of walleye pollock (Theragra chalcogramma). – ICES Journal of Marine …

Importance Low-density lipoprotein cholesterol (LDL-C)–lowering alleles in or
nearNPC1L1orHMGCR, encoding the respective molecular targets of ezetimibe and statins, have …

The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds
90% when diagnosed after age 65. Most cases arise without any detectable early symptoms …

Background Recent reports of patients with coronavirus disease 2019 (COVID-19) developing
pneumothorax correspond mainly to case reports describing mechanically ventilated …

New ventures face both liabilities of newness and smallness, which may inhibit their innovation
efforts and output. However, existing research has not clearly distinguished between the …

Invasion of the maxillary sinus is a relatively frequent complication in dental implant treatment
of patients with inadequate bone height in the posterior maxilla. This event usually occurs …

As atmospheric concentrations of CO 2 rise, the pH of high-latitude oceans is predicted to
decrease by 0.3 to 0.5 units by 2100. Several biological consequences of ocean acidification …