Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation
…, M Barshishat-Kupper, SR Mog, EA McCart… - Journal of radiation …, 2008 - jstage.jst.go.jp
The effects of genistein on 30-day survival and delayed lung injury were examined in C57BL/6J
female mice. A single subcutaneous injection of vehicle (PEG-400) or genistein (200 mg/…
female mice. A single subcutaneous injection of vehicle (PEG-400) or genistein (200 mg/…
[HTML][HTML] Hepatocyte growth factor isoforms in tissue repair, cancer, and fibrotic remodeling
O Mungunsukh, EA McCart, RM Day - Biomedicines, 2014 - mdpi.com
Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a pleotropic factor
required for normal organ development during embryogenesis. In the adult, basal expression of …
required for normal organ development during embryogenesis. In the adult, basal expression of …
[HTML][HTML] Delayed captopril administration mitigates hematopoietic injury in a murine model of total body irradiation
EA McCart, YH Lee, J Jha, O Mungunsukh… - Scientific Reports, 2019 - nature.com
The increasing potential for accidental radiation exposure from either nuclear accidents or
terrorist activities has escalated the need for radiation countermeasure development. We …
terrorist activities has escalated the need for radiation countermeasure development. We …
Mechanism of erythropoietin regulation by angiotensin II
YC Kim, O Mungunsukh, EA McCart, PJ Roehrich… - Molecular …, 2014 - ASPET
Erythropoietin (EPO) is the primary regulator of red blood cell development. Although hypoxic
regulation of EPO has been extensively studied, the mechanism(s) for basal regulation of …
regulation of EPO has been extensively studied, the mechanism(s) for basal regulation of …
Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury
EA McCart, RL Thangapazham… - Journal of Radiation …, 2017 - academic.oup.com
Accidental high-dose radiation exposures can lead to multi-organ injuries, including radiation
dermatitis. The types of cellular damage leading to radiation dermatitis are not completely …
dermatitis. The types of cellular damage leading to radiation dermatitis are not completely …
Captopril reduces lung inflammation and accelerated senescence in response to thoracic radiation in mice
O Mungunsukh, J George, EA McCart… - Journal of Radiation …, 2021 - academic.oup.com
The lung is sensitive to radiation and exhibits several phases of injury, with an initial phase
of radiation-induced pneumonitis followed by delayed and irreversible fibrosis. The …
of radiation-induced pneumonitis followed by delayed and irreversible fibrosis. The …
Effect of ionizing radiation on liver protein oxidation and metabolic function in C57BL/6J mice
…, AJ Tipton, EA McCart… - … journal of radiation …, 2014 - Taylor & Francis
Purpose: Protein oxidation in response to radiation results in DNA damage, endoplasmic
reticulum stress/unfolded protein response, cell cycle arrest, cell death and senescence. The …
reticulum stress/unfolded protein response, cell cycle arrest, cell death and senescence. The …
[HTML][HTML] Captopril modulates hypoxia-inducible factors and erythropoietin responses in a murine model of total body irradiation
…, O Mungunsukh, AJ Tipton, EA McCart… - Experimental …, 2011 - Elsevier
OBJECTIVE: Our laboratory reported that the angiotensin converting enzyme inhibitor captopril
improves erythroid recovery from total body irradiation (TBI) in mice when administered …
improves erythroid recovery from total body irradiation (TBI) in mice when administered …
[HTML][HTML] Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome
WB Rittase, EA McCart, JM Muir, RM Bouten… - Plos one, 2021 - journals.plos.org
Our laboratory has demonstrated that captopril, an angiotensin converting enzyme inhibitor,
mitigates hematopoietic injury following total body irradiation in mice. Improved survival in …
mitigates hematopoietic injury following total body irradiation in mice. Improved survival in …
[HTML][HTML] Bone marrow protein oxidation in response to ionizing radiation in C57BL/6J mice
YC Kim, M Barshishat-Kupper, EA McCart, GP Mueller… - Proteomes, 2014 - mdpi.com
The bone marrow is one of the most radio-sensitive tissues. Accidental ionizing radiation
exposure can damage mature blood cells and hematopoietic progenitor/stem cells, and …
exposure can damage mature blood cells and hematopoietic progenitor/stem cells, and …