A large diversity of 2-aminoimidazolone alkaloids is produced by various marine invertebrates,
especially by the marine Calcareous sponges Leucetta and Clathrina. The phylogeny of …

Growing evidence supports the implication of DYRK1A in the development of cognitive deficits
seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that …

Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine
phosphorylation-regulated kinase 1 A) in Alzheimer’s disease (AD). Here we showed that DYRK1A …

Electron transfer (ET) kinetic rate constants k s in Ethaline (1:2 choline chloride + ethylene
glycol) have been measured for two common redox couples (ferrocene/ferrocenium and …

Deep eutectic solvents (DES) are currently developed as ecofriendly and efficient solvents
for polyphenol extraction. However, a challenge remains in these processes concerning …

The protein kinase DYRK1A is involved in Alzheimer’s disease, Down syndrome, diabetes,
viral infections, and leukemia. Leucettines, a family of 2-aminoimidazolin-4-ones derived …

Classical electrochemical approaches were evaluated for investigating the basic properties
of deep eutectic solvents (DES) with a special focus on the mass transport phenomena and …

Leucettines, a family of marine sponge-derived 2-aminoimidazolone alkaloids, are potent
inhibitors of DYRKs (dual-specificity, tyrosine phosphorylation regulated kinases) and CLKs (…

Leucettines, a family of pharmacological inhibitors of dual-specificity tyrosine phosphorylation
regulated kinases and cdc-like kinases (CLKs), are currently under investigation for their …

Here, we report on the synthesis of libraries of new 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones
3 (twenty-two compounds) and new 2-amino-5-arylidene-1,3-thiazol-4(5H)-ones 5 (twenty…