User profiles for Eric Chun Yong Chan

Eric Chun Yong Chan

Professor (Department of Pharmacy, Faculty of Science), National University of Singapore
Verified email at nus.edu.sg
Cited by 5813

Metabolic profiling of human colorectal cancer using high-resolution magic angle spinning nuclear magnetic resonance (HR-MAS NMR) spectroscopy and gas …

ECY Chan, PK Koh, M Mal, PY Cheah… - Journal of proteome …, 2009 - ACS Publications
Current clinical strategy for staging and prognostication of colorectal cancer (CRC) relies
mainly upon the TNM or Duke system. This clinicopathological stage is a crude prognostic …

Global urinary metabolic profiling procedures using gas chromatography–mass spectrometry

ECY Chan, KK Pasikanti, JK Nicholson - Nature protocols, 2011 - nature.com
The role of urinary metabolic profiling in systems biology research is expanding. This is
because of the use of this technology for clinical diagnostic and mechanistic studies and for the …

Noninvasive urinary metabonomic diagnosis of human bladder cancer

…, R Kamaraj, QH Wu, E Chiong, ECY Chan - Journal of proteome …, 2010 - ACS Publications
Cystoscopy is considered the gold standard for the clinical diagnosis of human bladder cancer
(BC). As cystoscopy is expensive and invasive, it may compromise patients’ compliance …

Zebrafish for drug toxicity screening: bridging the in vitro cell-based models and in vivo mammalian models

H Sukardi, HT Chng, ECY Chan, Z Gong… - Expert opinion on drug …, 2011 - Taylor & Francis
Introduction: Over the past decade, zebrafish have been tasked to play important roles from
modeling human diseases to finding cures for them. Inadvertently, these fish now find …

Use of urine volatile organic compounds to discriminate tuberculosis patients from healthy subjects

KM Banday, KK Pasikanti, ECY Chan, R Singla… - Analytical …, 2011 - ACS Publications
Development of noninvasive methods for tuberculosis (TB) diagnosis, with the potential to be
administered in field situations, remains as an unmet challenge. A wide array of molecules …

Plasma metabonomic profiling of diabetic retinopathy

…, CMG Cheung, RW Beuerman, L Zhou, ECY Chan… - Diabetes, 2016 - Am Diabetes Assoc
Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and
the leading cause of visual impairment in working-age adults. Patients with diabetes often …

A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema

LDH Ta, JCY Chan, GC Yap, RW Purbojati… - Gut …, 2020 - Taylor & Francis
Evidence is accumulating that the establishment of the gut microbiome in early life influences
the development of atopic eczema. In this longitudinal study, we used integrated multi-…

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

…, AJ Dupuy, RL Johnson, GK Radda, ECY Chan… - Nature …, 2014 - nature.com
The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic
infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC, …

Mechanism-based inactivation of cytochrome P450 3A4 by lapatinib

…, MD Wahlin, SD Nelson, HK Ho, ECY Chan - Molecular …, 2010 - ASPET
Fatalities stemming from hepatotoxicity associated with the clinical use of lapatinib (Tykerb),
an oral dual tyrosine kinase inhibitor (ErbB-1 and ErbB-2) used in the treatment of metastatic …

Urinary metabotyping of bladder cancer using two-dimensional gas chromatography time-of-flight mass spectrometry

…, E Chiong, ECY Chan - Journal of proteome …, 2013 - ACS Publications
Cystoscopy is the gold standard clinical diagnosis of human bladder cancer (BC). As
cystoscopy is expensive and invasive, it compromises patients’ compliance toward surveillance …