Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway

…, EJ Gapud, BP Sleckman, T Sullivan, J Sage… - The EMBO …, 2009 - embopress.org
A‐type lamins are intermediate filament proteins that provide a scaffold for protein complexes
regulating nuclear structure and function. Mutations in the LMNA gene are linked to a …

DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

…, B Calderon, LM McGinnis, GK Mahowald, EJ Gapud… - Nature, 2008 - nature.com
DNA double-strand breaks are generated by genotoxic agents and by cellular endonucleases
as intermediates of several important physiological processes. The cellular response to …

Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation

EJ Gapud, Y Dorsett, B Yin, E Callen… - Proceedings of the …, 2011 - National Acad Sciences
Lymphocyte antigen receptor gene assembly occurs through the process of V(D)J
recombination, which is initiated when the RAG endonuclease introduces DNA DSBs at two …

Laulimalide and paclitaxel: a comparison of their effects on tubulin assembly and their synergistic action when present simultaneously

EJ Gapud, R Bai, AK Ghosh, E Hamel - Molecular pharmacology, 2004 - ASPET
Previous work has shown that laulimalide, a sponge-derived natural product, resembles
paclitaxel in enhancing tubulin assembly and in its effects on cellular microtubules. The two …

Unique and redundant functions of ATM and DNA-PKcs during V (D) J recombination

EJ Gapud, BP Sleckman - Cell cycle, 2011 - Taylor & Francis
Lymphocyte antigen receptor genes are assembled through the process of V(D)J recombination,
during which pairwise DNA cleavage of gene segments results in the formation of four …

Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V (D) J recombination

BS Lee, EJ Gapud, S Zhang, Y Dorsett… - … and cellular biology, 2013 - Taylor & Francis
V(D)J recombination is initiated by the RAG endonuclease, which introduces DNA double-strand
breaks (DSBs) at the border between two recombining gene segments, generating two …

ANCA-associated vasculitis pathogenesis: a commentary

EJ Gapud, P Seo, B Antiochos - Current rheumatology reports, 2017 - Springer
Purpose of Review The ANCA-associated vasculitides are a group of small vessel vasculitides
characterized by autoantibodies recognizing the neutrophil cytoplasmic antigens PR3 …

Granzyme B induces IRF-3 Phosphorylation through a perforin-independent proteolysis-dependent signaling cascade without inducing cell death

EJ Gapud, MI Trejo-Zambrano… - The Journal of …, 2021 - journals.aai.org
Granzyme B (GrB) is an immune protease implicated in the pathogenesis of several human
diseases. In the current model of GrB activity, perforin determines whether the downstream …

[HTML][HTML] Immunotherapy for ANCA-associated vasculitis during the COVID-19 pandemic

EJ Gapud, A Kronbichler, P Gauckler… - European Journal of …, 2020 - ncbi.nlm.nih.gov
Since the first description of infections with severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) in China in December 2019, it has evolved into a pandemic and emerged as …

Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites

EJ Gapud, BS Lee, GK Mahowald… - The Journal of …, 2011 - journals.aai.org
Ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase catalytic subunits (DNA-PKcs)
are members of the phosphatidylinositol 3-like family of serine/threonine kinases …