Spreading convulsions, spreading depolarization and epileptogenesis in human cerebral cortex
…, JA Hartings, M Fabricius, EJ Speckmann… - Brain, 2012 - academic.oup.com
Spreading depolarization of cells in cerebral grey matter is characterized by massive ion
translocation, neuronal swelling and large changes in direct current-coupled voltage recording. …
translocation, neuronal swelling and large changes in direct current-coupled voltage recording. …
Melatonin receptors in rat hippocampus: molecular and functional investigations
…, E Berger, JD Fauteck, EJ Speckmann - …, 2002 - Wiley Online Library
Since binding sites for melatonin have been found in the hippocampus of several mammals,
it has been suggested that the pineal hormone melatonin is able to modulate neuronal …
it has been suggested that the pineal hormone melatonin is able to modulate neuronal …
Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with …
…, A Ebner, A Gorji, H Straub, EJ Speckmann… - …, 2006 - Wiley Online Library
Purpose: The mechanisms of drug resistance in epilepsy are only incompletely understood.
According to a current concept, overexpression of drug efflux transporters at the blood–brain …
According to a current concept, overexpression of drug efflux transporters at the blood–brain …
Reduction of voltage-operated potassium currents by levetiracetam: a novel antiepileptic mechanism of action?
…, E Siep, P Boerrigter, H Klitgaard, EJ Speckmann - …, 2003 - Elsevier
Levetiracetam (ucb L059; Keppra™) is a novel antiepileptic drug. Its effects on action potential
generation and voltage-operated potassium currents were studied in acutely isolated …
generation and voltage-operated potassium currents were studied in acutely isolated …
Spontaneous sharp waves in human neocortical slices excised from epileptic patients.
…, A Lücke, H Straub, EJ Speckmann… - Brain: a journal of …, 1998 - academic.oup.com
Human neocortical temporal lobe tissue resected for treatment of pharmacoresistant
epilepsy was investigated. In slices prepared from this tissue, field potentials sometimes …
epilepsy was investigated. In slices prepared from this tissue, field potentials sometimes …
Spreading depression in human neocortical slices
…, P Wolf, HW Panneck, F Oppel, EJ Speckmann - Brain research, 2001 - Elsevier
Cortical spreading depression (CSD) occurrence has been suggested to be associated with
seizures, migraine aura, head injury and brain ischemia-infarction. Only few studies …
seizures, migraine aura, head injury and brain ischemia-infarction. Only few studies …
Gene expression and functional characterization of melatonin receptors in the spinal cord of the rat: implications for pain modulation
…, T Lansmann, E Berger, EJ Speckmann… - Journal of pineal …, 2003 - Wiley Online Library
Recently, a species‐dependent distribution of melatonin binding sites have been found in
lamina I–V and lamina X of the spinal cord. In order to learn more about the function of spinal …
lamina I–V and lamina X of the spinal cord. In order to learn more about the function of spinal …
DC potentials of the cerebral cortex: Seizure activity and changes in gas pressures
H Caspers, EJ Speckmann, A Lehmenkühler - Reviews of Physiology …, 1987 - Springer
The term" DC potentials" denotes bioelectrical phenomena produced by cerebral structures
such as the cortex in a frequency band ranging from EEG waves to ultraslow fluctuations …
such as the cortex in a frequency band ranging from EEG waves to ultraslow fluctuations …
Epileptiform activity preferentially arises outside tumor invasion zone in glioma xenotransplants
R Köhling, V Senner, W Paulus, EJ Speckmann - Neurobiology of disease, 2006 - Elsevier
Seizures occur commonly with brain tumors. The underlying mechanisms are not understood.
We analyzed network and cellular excitability changes in tumor-invaded and sham …
We analyzed network and cellular excitability changes in tumor-invaded and sham …
Interictal-like network activity and receptor expression in the epileptic human lateral amygdala
S Graebenitz, O Kedo, EJ Speckmann, A Gorji… - Brain, 2011 - academic.oup.com
While the amygdala is considered to play a critical role in temporal lobe epilepsy,
conclusions on underlying pathophysiological mechanisms have been derived largely from …
conclusions on underlying pathophysiological mechanisms have been derived largely from …