A variety of signaling proteins form heterocomplexes with and are regulated by the heat
shock protein chaperone hsp90. These complexes are formed by a multiprotein machinery, …

It is established that neuronal NO synthase (nNOS) is associated with the chaperone hsp90,
although the functional role for this interaction has not been defined. We have discovered …

Nitric oxide synthase (NOS) is a highly regulated enzyme that produces nitric oxide, a critical
messenger in many physiological processes. In this perspective, we explore the role of …

Lipophilic molecules, like chlorpyrifos (CPF), present a special problem for interpretation of
biomonitoring data because both the environmental dose of CPF and the physiological (…

It is established that neuronal NO synthase (nNOS) is ubiquitinated and proteasomally degraded.
The metabolism-based inactivation of nNOS and the inhibition of heat shock protein 90 …

It has been shown that administration of cigarette smoke to rats leads to loss of neuronal
nitric-oxide synthase (nNOS) activity and nNOS protein in penile tissue. The exact mechanism …

… Ezra R. Lowe … The calibration curve for LE ranged from 0.004 to 0.5 mg/g and was
found to be linear (R 2 = 0.99997). All samples analyzed fell within the calibration curve. …

Smoking causes a dysfunction in endothelial nitric-oxide synthase (eNOS), which is ameliorated,
in part, by administration of tetrahydrobiopterin (BH 4 ). The exact mechanism by which …

An understanding of the physiological factors that regulate perinatal dosimetry is essential
to improve the ability of physiologically based (PB) pharmacokinetic (PK) models to predict …

Chlorpyrifos (CPF) is a widely used organophosphate insecticide. In addition to its known
properties of cholinesterase inhibition, the production of reactive oxygen species (ROS) has …