Cellular myosin II is the principal motor responsible for cytokinesis. In higher eukaryotes,
phosphorylation of the regulatory light chain (MLC) of myosin II is a primary means of activating …

… and T855 are the inhibitory/regulatory sites phosphorylated by several kinases [1],
notably Rho-kinase (ROK); and S473 is phosphorylated during mitosis, probably by cdc2 (Matsumura, …

… Wong, CF Vogel and F. Matsumura, unpublished data). A better understanding of the
overexpression of inflammatory markers such as IL-8 in breast cancer is crucial to get a better …

Diabetes, a disease in which carbohydrate and lipid metabolism are regulated improperly by
insulin, is a serious worldwide health issue 1 , 2 . Insulin is secreted from pancreatic β cells …

Why are books written? Since I have read many works by my colleagues with admiration,
this question has always intrigued me. Further, writing a book takes a good deal of time and …

ROCK (Rho-kinase), an effector molecule of RhoA, phosphorylates the myosin binding
subunit (MBS) of myosin phosphatase and inhibits the phosphatase activity. This inhibition …

p21-activated kinases (PAKs) are implicated in the cytoskeletal changes induced by the
Rho family of guanosine triphosphatases. Cytoskeletal dynamics are primarily modulated by …

… We compared the subcellular distribution of phosphorylated MBS with that of F-actin and
phosphorylated MLC at Ser-19 in migrating MDCK cells. Between 2 and 16 h after the addition …

A critical role for the small GTPase Rho and one of its targets, p160ROCK (a Rho-associated
coiled coil-forming protein kinase), in neurite remodeling was examined in neuroblastoma …

… the distance of migration was shown in c, f, i, and l by connecting two centers. This analysis
shows that the inhibition of MLCK reduced net translocation (f). In contrast, the inhibition of …